Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease

dc.creatorZelazny, Adrian M.
dc.creatorDing, Li
dc.creatorElloumi, Houda Z.
dc.creatorBrinster, Lauren R.
dc.creatorBenedetti, Fran
dc.creatorCzapiga, Meggan
dc.creatorUlrich, Ricky L.
dc.creatorBallentine, Samuel J.
dc.creatorGoldberg, Joanna B.
dc.creatorSampaio, Elizabeth P.
dc.creatorHolland, Steven M.
dc.date2018-09-25T15:23:56Z
dc.date2018-09-25T15:23:56Z
dc.date2009
dc.date.accessioned2023-09-26T22:06:05Z
dc.date.available2023-09-26T22:06:05Z
dc.identifierZELAZNY, Adrian M. et al. Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease. Infection and Immunity, v.77, n.10, p.4337-4344, Oct. 2009.
dc.identifier0019-9567
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29042
dc.identifier10.1128/IAI.00259-09
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874741
dc.descriptionChronic granulomatous disease (CGD) patients are susceptible to life-threatening infections by the Burkholderia cepacia complex. We used leukocytes from CGD and healthy donors and compared cell association, invasion, and cytokine induction by Burkholderia multivorans strains. A CGD isolate, CGD1, showed higher cell association than that of an environmental isolate, Env1, which correlated with cell entry. All B. multivorans strains associated significantly more with cells from CGD patients than with those from healthy donors. Similar findings were observed with another CGD pathogen, Serratia marcescens, but not with Escherichia coli. In a mouse model of CGD, strain CGD1 was virulent while Env1 was avirulent. B. multivorans organisms were found in the spleens of CGD1-infected mice at levels that were 1,000 times higher than those found in Env1-infected mice, which was coincident with higher levels of the proinflammatory cytokine interleukin-1 . Taken together, these results may shed light on the unique susceptibility of CGD patients to specific pathogens.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.rightsopen access
dc.subjectDoença granulomatosa crônica
dc.subjectVirulência
dc.subjectInterações celulares
dc.subjectBurkholderia multivorans
dc.subjectChronic granulomatous disease
dc.subjectVirulence
dc.subjectCellular Interactions
dc.subjectBurkholderia multivorans
dc.titleVirulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease
dc.typeArticle


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