Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis

dc.creatorSantos, Hayna Malta
dc.creatorFukutani, Kyoshi F.
dc.creatorSorgi, Carlos A.
dc.creatorQueiroz, Artur T. L.
dc.creatorNardini, Viviane
dc.creatorSilva, Juliana
dc.creatorLago, Alex
dc.creatorCarvalho, Lucas P.
dc.creatorMachado, Paulo L. R.
dc.creatorBozza, Patrícia T.
dc.creatorCosta, Jaqueline França
dc.creatorFaccioli, Lúcia Helena
dc.creatorCarvalho, Edgar M.
dc.creatorAndrade, Bruno de Bezerril
dc.creatorBorges, Viviane M.
dc.date2020-12-10T14:35:39Z
dc.date2020-12-10T14:35:39Z
dc.date2020
dc.date.accessioned2023-09-26T22:05:48Z
dc.date.available2023-09-26T22:05:48Z
dc.identifierSANTOS, Hayna Malta et al. Multi-omic Analyses of Plasma Cytokines, Lipidomics, and Transcriptomics Distinguish Treatment Outcomes in Cutaneous Leishmaniasis. iScience, v. 23, n. 12, 101840, 30p, Dec. 2020.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44781
dc.identifier10.1016/j.isci.2020.101840
dc.identifier2589-0042
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874676
dc.descriptionLeishmania braziliensis infection frequently results in cutaneous leishmaniasis (CL). An increase in incidence of drug-resistant CL leading to treatment failure has been reported. Identification of reliable predictors of treatment outcomes is necessary to optimize patient care. Here, we performed a prospective case-control study in which plasma levels of cytokines and lipid mediators were assessed at different time points during antileishmanial therapy in patients with CL from Brazil. Multidimensional analyses were employed to describe a combination of biomarkers able to predict and characterize treatment failure. We found a biosignature influenced mainly by plasma levels of lipid mediators that accurately predicted treatment failure. Furthermore, transcriptomic analysis of a publicly available data set revealed that expression levels of genes related to lipid metabolism measured in skin lesions could distinguish treatment outcomes in CL. Thus, activation of pathways linked to lipid biosynthesis predicts treatment failure in CL. The biomarkers identified may be further explored as therapeutic targets.
dc.formatapplication/pdf
dc.languageeng
dc.publisherScience
dc.rightsopen access
dc.subjectAnálises multiômicas
dc.subjectCitocinas plasmáticas
dc.subjectLipidômica
dc.subjectTranscriptômica
dc.subjectResultados no tratamento
dc.subjectCutaneous Leishmaniasis
dc.subjectMulti-omic analysis
dc.subjectPlasma Cytokines
dc.subjectTranscriptomics
dc.subjectTreatment
dc.titleMulti-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis
dc.typeArticle


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