The phenotypic spectrum of congenital Zika syndrome

dc.creatorDel Campo, Miguel
dc.creatorFeitosa, Ian M. L.
dc.creatorRibeiro, Erlane M.
dc.creatorHorovitz, Dafne D. G.
dc.creatorPessoa, André L.S.
dc.creatorFrança, Giovanny V. A.
dc.creatorGarcía-Alix, Alfredo
dc.creatorDoriqui, Maria J. R.
dc.creatorWanderley, Hector Y. C.
dc.creatorSanseverino, Maria V. T.
dc.creatorNeri, João I. C. F.
dc.creatorPina-Neto, João M.
dc.creatorSantos, Emerson S.
dc.creatorVerçosa, Islane
dc.creatorCernach, Mirlene C. S. P.
dc.creatorMedeiros, Paula F. V.
dc.creatorKerbage, Saile C.
dc.creatorSilva, André A.
dc.creatorvan der Linden, Vanessa
dc.creatorMartelli, Celina Maria Turchi
dc.creatorCordeiro, Marli T.
dc.creatorDhalia, Rafael
dc.creatorVianna, Fernanda S. L.
dc.creatorVictora, Cesar G.
dc.creatorCavalcanti, Denise P.
dc.creatorSchuler-Faccini, Lavinia
dc.date2017-03-29T19:28:29Z
dc.date2017-03-29T19:28:29Z
dc.date2017
dc.date.accessioned2023-09-26T22:04:56Z
dc.date.available2023-09-26T22:04:56Z
dc.identifierDEL CAMPO, Miguel. etal. The phenotypic spectrum of congenital Zika syndrome. American Journal of Medical Genetics Part A. v. 173, n. 4, p. 841-857, 2017
dc.identifier1552-4833
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18201
dc.identifier10.1002/ajmg.a.38170
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874604
dc.descriptionIn October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF. A recognizable phenotype of microcephaly, anomalies of the shape of skull and redundancy of the scalp consistent with the Fetal Brain Disruption Sequence (FBDS) was present in 70% of infants, but was most often subtle. In addition, features consistent with fetal immobility, ranging from dimples (30.1%), distal hand/finger contractures (20.5%), and feet malpositions (15.7%), to generalized arthrogryposis (9.6%), were present in these infants. Some cases had milder microcephaly or even a normal head circumference (HC), and other less distinctive findings. The detailed observation of the dysmorphic and neurologic features in these infants provides insight into the mechanisms and timings of the brain disruption and the sequence of developmental anomalies that may occur after prenatal infection by the ZIKV.
dc.description2018-03-22
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectZika virus
dc.subjectCongenital Zika sequence
dc.subjectCongenital Zika Sequence
dc.subjectCongenital Zika Ssyndrome
dc.subjectDisruption
dc.subjectDisruptive Sequence
dc.subjectDysmorphology
dc.subjectFetal Brain Disruption Sequence
dc.subjectTeratogen
dc.subjectTeratology
dc.subjectZika Virus
dc.subjectZika virus
dc.titleThe phenotypic spectrum of congenital Zika syndrome
dc.typeArticle


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