Bone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas' disease

dc.creatorVilas-Boas, Fábio
dc.creatorFeitosa, Gilson Soares
dc.creatorSoares, Milena Botelho Pereira
dc.creatorPinho Filho, Joel Alves
dc.creatorMota, Augusto César de Andrade
dc.creatorAlmeida, Augusto José Gonçalves de
dc.creatorCarvalho, Cristiane Costa
dc.creatorCarvalho, Heitor Ghissoni de
dc.creatorOliveira, Adriano Dourado de
dc.creatorSantos, Ricardo Ribeiro dos
dc.date2011-12-01T18:55:29Z
dc.date2011-12-01T18:55:29Z
dc.date2004
dc.date.accessioned2023-09-26T22:04:15Z
dc.date.available2023-09-26T22:04:15Z
dc.identifierVILAS-BOAS, F. et al. Bone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas' disease. Arquivos Brasileiros de Cardiologia, v. 82, n. 2, p. 185-187, fev. 2004.
dc.identifier0066-782X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3698
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874565
dc.descriptionWe report the first case of bone marrow cell transplantation to the myocardium of a patient with heart failure due to chagas' disease. The patient is a 52-year-old man with chronic heart failure, NYHA functional class III, despite the optimized clinical therapy. The procedure consisted of aspiration of 50 mL of bone marrow through puncture of the iliac crest, followed by filtration, separation of the mononuclear cells, resuspension, and intracoronary injection. The left ventricular ejection fraction at rest, measured using radionuclide ventriculography with labeled red blood cells prior to transplantation, was 24%, and, after 30 days, it increased to 32% with no change in the medicamentous schedule. The following measurements were assessed before and 30 days after transplantation: left ventricular end diastolic diameter (82 mm and 76 mm, respectively); Minnesota living with heart failure questionaire score (55 and 06, respectively); and distance walked in the 6-minute walking test (513 m and 683 m, respectively). Our findings show that intracoronary injection of bone marrow cells may be performed, suggesting that this is a potentially safe and effective procedure in patients with due to Chagas' disease heart failure.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectTransplante de Medula Óssea
dc.subjectBaixo Débito Cardíaco
dc.subjectCardiomiopatia Chagásica
dc.subjectDoença Crônica
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectMiocárdio
dc.titleBone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas' disease
dc.typeArticle


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