Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure

dc.creatorFriani, Gabriela
dc.creatorCosta, Valdir A.
dc.creatorMota, Ester
dc.creatorFaro, Marta Júlia
dc.creatorSouza, Samaly
dc.creatorFigueiredo, Marcela
dc.creatorGôlo, Patrícia S.
dc.creatorSilva, Clélia Christina
dc.date2022-07-22T21:00:24Z
dc.date2022-07-22T21:00:24Z
dc.date2022
dc.date.accessioned2023-09-26T22:04:01Z
dc.date.available2023-09-26T22:04:01Z
dc.identifierFRIANI, Gabriela et al. Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure. An Acad Bras Ciências, Rio de Janeiro, v. 94, n. 2, e20190676, p. 1 - 10, 2022.
dc.identifier1678-2690
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53922
dc.identifier10.1590/0001-3765202220200620
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874551
dc.descriptionSchistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni. Uninfected and infected snails were exposed to sublethal concentration of E. milii latex for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni, the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland and kidney. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells. We conclude that the E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the destruction of parasites.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAcademia Brasileira de Ciências
dc.rightsopen access
dc.subjectBiomphalaria
dc.subjectGlabrata
dc.subjectEuphorbia milii
dc.subjectHemócitos
dc.subjectFitoquímico
dc.subjectSuscetibilidade
dc.subjectBiomphalaria
dc.subjectGlabrata
dc.subjectEuphorbia milii
dc.subjectHemocytes
dc.subjectPhytochemical
dc.subjectSusceptibility
dc.titleDestruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
dc.typeArticle


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