New imidazolidine derivatives as anti-Trypanosoma cruzi agents: structure-activity relationships

dc.creatorGomes, Fabiana Oliveira dos Santos
dc.creatorMelo, Cristiane Moutinho Lagos de
dc.creatorPeixoto, Christina Alves
dc.creatorLima, Maria do Carmo Alves de
dc.creatorGaldino, Suely Lins
dc.creatorPereira, Valéria Rêgo Alves
dc.creatorPitta, Ivan da Rocha
dc.date2019-02-06T13:16:13Z
dc.date2019-02-06T13:16:13Z
dc.date2012
dc.date.accessioned2023-09-26T22:02:30Z
dc.date.available2023-09-26T22:02:30Z
dc.identifierDOS SANTOS GOMES, Fabiana Oliveira et al. New Imidazolidine Derivatives as Anti-Trypanosoma Cruzi Agents: Structure–Activity Relationships. Parasitology Research, v. 111, n. 6, p. 2361–2366, 1 dez. 2012.
dc.identifier1432-1955
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31450
dc.identifier10.1007/s00436-012-3091-7
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874461
dc.descriptionF.O.S. Gomes received a CNPq MSc scholarship for the duration of this research project.
dc.descriptionImidazolidine derivatives are key components for the development of bioactive compounds for the treatment of many diseases, especially Chagas. In fact, others studies showed that the imidazolidine-2,4-dione has stood out by presenting a wide spectrum of pharmacological activities including anticonvulsants, antiarrhythmic, and antiparasitic. In the present study, we investigated the morphological alterations induced by imidazolidine derivates LPSF/NN-52 and LPSF/NN-100 on trypomastigotes forms of Trypanosoma cruzi through ultrastructural analysis by electron microscopy. Many concentrations were used to measure the antiparasitic propriety promoted by imidazolidine derivatives, and our study indicates that parasites treated with 13 μg mL(-1) of the imidazolidine derivates for 24 h revealed severe damage to the parasite's mitochondrial complex. Beyond that, also observed in treated parasites were the following: myelin bodies, enlargement of cytoplasm vacuole, fragmentation of endoplasmic reticulum, and some treated samples clearly showed signs of necrosis. To confirm the ultrastructural results, some assays were performed for knowledge cellular death induction promoted by imidazolidine derivates against immune spleen cells. The induction of the necrotic process through derivatives LPSF/NN-52 and LPSF/NN-100 showed similar results in relation to nifurtimox and benznidazole. In the last assays, it was demonstrated that NN-100 was efficient against epimastigotes and trypomastigotes forms and these results reinforce the mechanisms of action of both new imidazolidine derivatives against T. cruzi.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectNitrofuran
dc.subjectImidazolidine
dc.subjectMouse Splenocytes
dc.subjectBenznidazole
dc.subjectCytoplasm Vacuole
dc.subjectImidazolidinas / química
dc.subjectImidazolidinas / farmacologia
dc.subjectMicroscopia Eletrônica
dc.subjectRelação Estrutura-Atividade
dc.subjectAgentes Tripanocidas / Química
dc.subjectTripanocidas Agentes / Farmacologia
dc.subjectTrypanosoma cruzi / efeitos de drogas
dc.subjectTrypanosoma cruzi / ultraestrutura
dc.titleNew imidazolidine derivatives as anti-Trypanosoma cruzi agents: structure-activity relationships
dc.typeArticle


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