Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state

dc.creatorMeurer, Igor Rosa
dc.creatorSilva, Marcio Roberto
dc.creatorSilva, Marcos Vinícius Ferreira
dc.creatorDuré, Ana Íris de Lima
dc.creatorAdelino, Talita Émile Ribeiro
dc.creatorCosta, Alana Vitor Barbosa da
dc.creatorVanelli, Chislene Pereira
dc.creatorGuimarães, Ricardo José de Paula Souza e
dc.creatorRozenthal, Tatiana
dc.creatorLemos, Elba Regina Sampaio de
dc.creatorCorrêa, José Otávio do Amaral
dc.date2022-03-20T14:18:27Z
dc.date2022-03-20T14:18:27Z
dc.date2021
dc.date.accessioned2023-09-26T22:01:57Z
dc.date.available2023-09-26T22:01:57Z
dc.identifierMEURER, Igor Rosa et al. Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state. Trans. R. Soc. Med Hyg., v. 0, p. 1 - 9, July 2021.
dc.identifier0035-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51755
dc.identifier10.1093/trstmh/trab113
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874429
dc.descriptionBackground: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and underreported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state. Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii-seropositive individuals and livestock concentration were evaluated. Results: We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti-C. burnetii antibodies (titer of ≥64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found. Conclusions: Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans in a state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies.
dc.description2023
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectCoxiella burnetii
dc.subjectQ fever
dc.subjectSaúde Pública
dc.subjectZoonose
dc.subjectSoroprevalência
dc.subjectCoxiella burnetii
dc.subjectPublic health
dc.subjectQ fever
dc.subjectSeroprevalence
dc.subjectZoonosis
dc.titleSeroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state
dc.typeArticle


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