Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children.

dc.creatorMoreira Júnior, Edson Duarte
dc.creatorNassri, Victor Bastos
dc.creatorSantos, Rafaela Sousa
dc.creatorMatos, Junísia Ferraz
dc.creatorCarvalho, Wilson Andrade de
dc.creatorSilvani, Célia Stolve
dc.creatorSant’Ana, Círia Santana e
dc.date2015-03-25T16:19:42Z
dc.date2015-03-25T16:19:42Z
dc.date2005
dc.date.accessioned2023-09-26T22:00:32Z
dc.date.available2023-09-26T22:00:32Z
dc.identifierMOREIRA JÚNIOR, E. D. et al. Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. World Journal of Gastroenterology, v. 11, n. 18, p. 2759-2763 , 2005.
dc.identifier1007-9327
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9827
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874352
dc.descriptionAIM: To investigate whether Helicobacter pylori (H pylori) infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure. METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital in Salvador, Brazil. H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) were found to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence of H pylori and HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for both H pylori and HAV antibodies (chi(2) = 7.18, OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI 1.02-5.03). The agreement between H pylori and HAV seropositivity was fair (kappa = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pylori were age, presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4, 95%CI, 1.1-5.1). CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted.
dc.formatapplication/pdf
dc.languageeng
dc.publisherThe WJG Press and Elsevier Inc.
dc.rightsopen access
dc.subjectH pylori
dc.subjectHepatitis A virus
dc.subjectEpidemiology
dc.subjectTransmission
dc.subjectEnteroparasites
dc.subjectBrazil
dc.subjectGiardíase/complicações
dc.subjectInfecções por Helicobacter/complicações
dc.subjectHelicobacter pylori
dc.subjectAnimais
dc.subjectBrasil
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectEstudos Transversais
dc.subjectPaíses em Desenvolvimento
dc.subjectFezes/parasitologia
dc.subjectFeminino
dc.subjectGiardia lamblia/isolamento & purificação
dc.subjectInfecções por Helicobacter/transmissão
dc.subjectHumanos
dc.subjectLactente
dc.subjectMasculino
dc.subjectPopulação Urbana
dc.titleAssociation of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children.
dc.typeArticle


Este ítem pertenece a la siguiente institución