Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil

dc.creatorBastos, Claudilson José de Carvalho
dc.creatorAras Junior, Roque
dc.creatorMota, Gildo de Oliveira
dc.creatorReis, Francisco
dc.creatorDias, Juarez Pereira
dc.creatorJesus, Robson Silva de
dc.creatorFreire, Miralba Silva
dc.creatorAraújo, Eline Gomes de
dc.creatorPrazeres, Juliana Moura Bastos
dc.creatorGrassi, Maria Fernanda Rios
dc.date2014-10-06T19:02:57Z
dc.date2014-10-06T19:02:57Z
dc.date2010
dc.date.accessioned2023-09-26T21:58:56Z
dc.date.available2023-09-26T21:58:56Z
dc.identifierBASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.
dc.identifier1935-2735
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8517
dc.identifier10.1371/journal.pntd.0000711
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874259
dc.descriptionBACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectDoença de Chagas
dc.subjectSurtos de Doenças
dc.subjectDoença Aguda
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectEpidemiologia
dc.subjectDiagnóstico
dc.subjectCriança
dc.subjectDoença de Chagas/quimioterapia
dc.subjectSurtos de Doenças
dc.subjectDoença Aguda
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectBrasil/epidemiologia
dc.subjectDoença de Chagas /diagnóstico
dc.subjectDoença de Chagas /epidemiologia
dc.subjectCriança
dc.subjectEcocardiografia Doppler
dc.subjectEletrocardiografia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectMasculino
dc.subjectNitroimidazóis /uso terapêutico
dc.subjectRadiografia Torácica
dc.subjectResultado do Tratamento
dc.subjectTripanossomicidas /uso terapêutico
dc.subjectTrypanosoma cruzi /isolamento & purificação
dc.titleClinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
dc.typeArticle


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