Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA

dc.creatorWay, Débora Vieira
dc.creatorBraido, Rayany Stôcco
dc.creatorReis, Sabrina Alves dos
dc.creatorLara, Flávio Alves
dc.creatorPinto, José Carlos
dc.date2019-09-05T13:00:02Z
dc.date2019-09-05T13:00:02Z
dc.date2019
dc.date.accessioned2023-09-26T21:57:59Z
dc.date.available2023-09-26T21:57:59Z
dc.identifierWAY, Débora Vieira et al. Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA. Nanomaterials, v. 9, n. 828, p. 1-16, 2019.
dc.identifier2079-4991
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/35350
dc.identifier10.3390/nano9060828
dc.identifier2079-4991
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874203
dc.descriptionPolymerization through reversible addition-fragmentation chain-transfer (RAFT) polymerization has been extensively employed for the production of polymers with controlled molar mass, complex architectures and copolymer composition distributions intended for biomedical and pharmaceutical applications. In the present work, RAFT miniemulsion copolymerizations of methyl methacrylate with acrylic acid and methacrylic acid were conducted to prepare hydrophilic polymer nanoparticles and compare cell uptake results after bioconjugation with bovine serum albumin (BSA), used as a model biomolecule. Obtained results indicate that the RAFT agent 2-cyano-propyl-dithiobenzoate allowed for successful free radical controlled methyl methacrylate copolymerizations and performed better when methacrylic acid was used as comonomer. Results also indicate that poly(methyl methacrylate-co-methacrylic acid) nanoparticles prepared by RAFT copolymerization and bioconjugated with BSA were exceptionally well accepted by cells, when compared to the other produced polymer nanoparticles because cellular uptake levels were much higher for particles prepared in presence of methacrylic acid, which can probably be associated to its high hydrophilicity.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectCopolímero
dc.subjectBioconjungação
dc.subjectTransferência de cadeia de adição-fragmentação reversível
dc.subjectRAFT
dc.subjectCopolymers
dc.subjectBioconjugation
dc.subjectMaleimide-PEG-NHS
dc.titleMiniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA
dc.typeArticle


Este ítem pertenece a la siguiente institución