Hepatitis C virus infection in patients with tuberculosis in Central Brazil

dc.creatorReis, N. R. S.
dc.creatorLopes, C. L. R.
dc.creatorTeles, S. A.
dc.creatorMatos, M. A .D.
dc.creatorCarneiro, M. A. S.
dc.creatorMarinho, T. A.
dc.creatorFilho, J. A. Araújo
dc.creatorEspírito Santo, M. P.
dc.creatorLampe, E.
dc.creatorMartins, R. M. B.
dc.date2017-11-01T10:19:07Z
dc.date2017-11-01T10:19:07Z
dc.date2011
dc.date.accessioned2023-09-26T21:56:07Z
dc.date.available2023-09-26T21:56:07Z
dc.identifierREIS, N. R. S. et al. Hepatitis C virus infection in patients with tuberculosis in Central Brazil. Int. J. Tuberc. Lung Dis., v. 15, n. 10, p.1397-1402, 2011.
dc.identifier1027-3719
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23011
dc.identifier10.5588/ijtld.10.0636
dc.identifier1815-7920
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8874102
dc.descriptionOBJECTIVES: To determine the prevalence of hepatitis C virus (HCV) infection, risk factors, HCV genotype/ subtype, HCV viral load and human immunodefi ciency virus (HIV) status in patients with tuberculosis (TB) in Central Brazil. DESIGN: A cross-sectional study was carried out with 402 patients who were under tuberculosis (TB) treatment in the reference hospital for infectious diseases in Goiânia, Goiás, Central Brazil. RESULTS: The prevalence rates of HCV and HIV were respectively 7.5% and 27.6%. Two thirds of the HCVinfected patients (20/30) were HIV-positive. Age, injecting drug use (IDU) and HIV status were factors independently associated with HCV infection. HCV RNA was detected in 23 serum samples; HCV RNA levels were measured in 22/23 samples. HCV RNA level was slightly higher in HCV-HIV co-infected patients than in HCV monoinfected patients. Genotypes 1 (n = 17) and 3 (n = 6) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 12), 1b (n = 2) and 3a (n = 6) were identifi ed. CONCLUSION: These data indicate that patients with TB may benefi t from integrated HIV and HCV screening, which may have an important impact upon TB management and treatment..
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.rightsrestricted access
dc.subjectTuberculose
dc.subjectVírus da hepatite C
dc.subjectEpidemiologia
dc.subjectBrasil
dc.subjecttuberculosis
dc.subjecthepatitis C virus
dc.subjectepidemic
dc.subjectBrazil
dc.titleHepatitis C virus infection in patients with tuberculosis in Central Brazil
dc.typeArticle


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