Efeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGanem, Eliana Marisa
dc.creatorVianna, Pedro Thadeu Galvão
dc.creatorCastiglia, Yara Marcondes Machado
dc.creatorBraz, José Reinaldo Cerqueira
dc.creatorDo Nascimento, P.
dc.creatorVanne, L. A.
dc.date2014-05-27T11:19:42Z
dc.date2016-10-25T18:15:35Z
dc.date2014-05-27T11:19:42Z
dc.date2016-10-25T18:15:35Z
dc.date1999-01-27
dc.date.accessioned2017-04-06T00:53:46Z
dc.date.available2017-04-06T00:53:46Z
dc.identifierRevista Brasileira de Anestesiologia, v. 49, n. 1, p. 35-37, 1999.
dc.identifier0034-7094
dc.identifierhttp://hdl.handle.net/11449/65709
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65709
dc.identifier2-s2.0-0032892828.pdf
dc.identifier2-s2.0-0032892828
dc.identifierhttp://www.sba.com.br/arquivos/revista/rba/jan99035.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887400
dc.descriptionBackground and Objectives. The analgesic actions of nonsteroidal anti-inflammatory drugs (NSAID) result from the inhibition of the peripheral synthesis of prostaglandins. In spite of the emphasis on the peripheral action, several studies have shown the potential central action of such drugs. In rats, NSAID doses insufficient to block pain when systemically administered were effective when intrathecally injected. This effect could be mediated by interaction with descending serotoninergic ways together with neurotransmission modulation of glycine or N-methyl-D-aspartate receptors. Our goal was to study the effect of different tenoxican doses in the histology of dogs spinal cord and meninges. Methods. Thirty two dogs (7 to 17 kg) were randomly distributed in four groups: G1 - Control with distilled water (DW); G2 - 2 mg tenoxican diluted in DW; G3 - 4 mg tenoxican diluted in DW; G4 - 10 mg tenoxican diluted in DW in a constant volume of 1 ml. Anesthesia was induced with etomidate and fentanyl and dural puncture was performed with a 25G spinal needle in interspace L6-7. Animals were observed for 72 hours and subsequently euthanized by electrocution. Lumbar and sacral spinal cord segments were removed for further histologic examination. Results. All animals were clinically normal during the observation period and there has been no histologic alteration of the nervous system and meninges. Conclusions. In our experimental model intrathecal tenoxican doses up to 10 mg have not triggered nervous tissue or meningeal injuries in dogs.
dc.languagepor
dc.relationRevista Brasileira de Anestesiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnesthetic techniques: regional, spinal block
dc.subjectAnimal: dog
dc.subjectAnti-inflammatory: tenoxican
dc.subjectetomidate
dc.subjectfentanyl
dc.subjectglycine
dc.subjectn methyl dextro aspartic acid receptor
dc.subjectnonsteroid antiinflammatory agent
dc.subjectprostaglandin
dc.subjecttenoxicam
dc.subjectanesthesia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdog
dc.subjectfemale
dc.subjecthistology
dc.subjectintrathecal drug administration
dc.subjectlumbar puncture
dc.subjectlumbar spinal cord
dc.subjectmale
dc.subjectmeninx
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectprostaglandin synthesis inhibition
dc.subjectrat
dc.subjectsacral spinal cord
dc.subjectserotoninergic system
dc.subjectspinal cord
dc.titleEfeitos de diferentes doses de tenoxicam sobre a medula espinhal e as meninges. Estudo experimental em caes
dc.typeOtro


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