Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

dc.creatorGouveia, Mateus Henrique
dc.creatorBergen, Andrew W.
dc.creatorBorda, Victor
dc.creatorNunes, Kelly
dc.creatorLeal, Thiago P.
dc.creatorOgwang, Martin D.
dc.creatorYeboah, Edward D.
dc.creatorMensah, James E.
dc.creatorKinyera, Tobias
dc.creatorOtim, Isaac
dc.creatorNabalende, Hadijah
dc.creatorLegason, Ismail D.
dc.creatorMpoloka, Sununguko Wata
dc.creatorMokone, Gaonyadiwe George
dc.creatorKerchan, Patrick
dc.creatorBhatia, Kishor
dc.creatorReynolds, Steven J.
dc.creatorBirtwum, Richard B.
dc.creatorAdjei, Andrew A.
dc.creatorTettey, Yao
dc.creatorTay, Evelyn
dc.creatorHoover, Robert
dc.creatorPfeiffer, Ruth M.
dc.creatorBiggar, Robert J.
dc.creatorGoedert, James J.
dc.creatorProkunina-Olsson, Ludmila
dc.creatorDean, Michael
dc.creatorYeager, Meredith
dc.creatorCosta, Maria Fernanda Furtado Lima
dc.creatorHsing, Ann W.
dc.creatorTishkoff, Sarah A.
dc.creatorChanock, Stephen J.
dc.creatorSantos, Eduardo Tarazona
dc.creatorMbulaiteye, Sam M.
dc.date2020-02-04T16:03:51Z
dc.date2020-02-04T16:03:51Z
dc.date2019
dc.date.accessioned2023-09-26T21:52:22Z
dc.date.available2023-09-26T21:52:22Z
dc.identifierGOUVEIA, Mateus Henrique et al. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genetics, v. 15, n. 3, p. 1-21, 2019.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39721
dc.identifier10.1371/journal.pgen.1008027
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873887
dc.descriptionPopulations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endemic Burkitt Lymphoma (eBL), a pediatric cancer that affects populations with intense malaria exposure, in the so called “eBL belt” in sub-Saharan Africa. However, the effects of intense malaria exposure and sub-Saharan populations’ genetic histories remain poorly explored. To determine if historical migrations and intense malaria exposure have shaped the genetic composition of the eBL belt populations, we genotyped ~4.3 million SNPs in 1,708 individuals from Ghana and Northern Uganda, located on opposite sides of eBL belt and with ≥ 7 months/year of intense malaria exposure and published evidence of high incidence of BL. Among 35 Ghanaian tribes, we showed a predominantly West-Central African ancestry and genomic footprints of gene flow from Gambian and East African populations. In Uganda, the North West population showed a predominantly Nilotic ancestry, and the North Central population was a mixture of Nilotic and Southern Bantu ancestry, while the Southwest Ugandan population showed a predominant Southern Bantu ancestry. Our results support the hypothesis of diverse ancestral origins of the Ugandan, Kenyan and Tanzanian Great Lakes African populations, reflecting a confluence of Nilotic, Cushitic and Bantu migrations in the last 3000 years. Natural selection analyses suggest, for the first time, a strong positive selection signal in the ATP2B4 gene (rs10900588) in Northern Ugandan populations. These findings provide important baseline genomic data to facilitate disease association studies, including of eBL, in eBL belt populations.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectUganda
dc.subjectAfrica
dc.subjectGhana
dc.subjectMalaria
dc.subjectUganda
dc.subjectAfrica
dc.subjectGhana
dc.subjectMalaria
dc.subjectGene flow
dc.subjectNatural selection
dc.subjectPopulation
dc.subjectGenetics
dc.subjectLakes
dc.titleGenetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"
dc.typeArticle


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