A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells

dc.creatorRomanos, M. T.
dc.creatorSerpa, M. J. A.
dc.creatorMourão, P. A.
dc.creatorValentin, Y. Y.
dc.creatorCosta, S. S.
dc.creatorPereira, M. S.
dc.creatorMiranda, M. M.
dc.creatorGonçalves, J. L.
dc.creatorWigg, M. D.
dc.date2019-05-17T14:11:52Z
dc.date2019-05-17T14:11:52Z
dc.date2002
dc.date.accessioned2023-09-26T21:50:31Z
dc.date.available2023-09-26T21:50:31Z
dc.identifierROMANOS, M. T. V. et al. A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells. Antiviral Chemistry and Chemotherapy, v. 13, n. 4, p. 219-221, 2002.
dc.identifier0956-3202
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33130
dc.identifier10.1177/095632020201300402
dc.identifier0956-3202
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873778
dc.descriptionMaria José de Andrada Serpa. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
dc.descriptionThis work evaluated the effect of a sulphated fucan extracted from the Laminaria abyssalis marine algae on the human T cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation. The experiments were carried out in HeLa cells cocultured with a HTLV-1-infected T cell line (C91/PL cells) in the presence of the sulphated polysaccharide at concentration below that corresponding to the ED50. The sulphated fucan inhibited almost 100% of the syncytium formation at concentration of 100 µg/ml and was still active (>95%) at a concentration of 25 µg/ml. It was also observed that the best inhibition occurred when the compound was added in the first 2 h of the cell-to-cell contact. This is the first report showing that a purified sulphated polysaccharide, extracted from marine algae, is able to inhibit the cell-tocell contact essential for the spreading of the HTLV-1.
dc.description2020-05-17
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publications
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectLaminaria abyssalis
dc.subjectMarine algae
dc.subjectSulphated fucan
dc.subjectSyncytium inhibition
dc.titleA sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells
dc.typeArticle


Este ítem pertenece a la siguiente institución