Analysis of Viral and Host Factors on Immunogenicity of 2018, 2019, and 2020 Southern Hemisphere Seasonal Trivalent Inactivated Influenza Vaccine in Adults in Brazil

dc.creatorCapão, Artur
dc.creatorOliveira, Maria L. Aguiar
dc.creatorCaetano, Braulia C.
dc.creatorNeves, Thayssa K.
dc.creatorResende, Paola C.
dc.creatorAlmeida, Walquiria A. F.
dc.creatorMiranda, Milene D.
dc.creatorMartins Filho, Olindo Assis
dc.creatorBrown, David
dc.creatorSiqueira, Marilda M.
dc.creatorGarcia, Cristiana
dc.date2022-10-11T11:00:22Z
dc.date2022-10-11T11:00:22Z
dc.date2022
dc.date.accessioned2023-09-26T21:49:19Z
dc.date.available2023-09-26T21:49:19Z
dc.identifierCAPÃO, Artur et al. Analysis of Viral and Host Factors on Immunogenicity of 2018, 2019, and 2020 Southern Hemisphere Seasonal Trivalent Inactivated Influenza Vaccine in Adults in Brazil. Viruses, v. 14, 1692, p. 1 - 18, July 2022.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55095
dc.identifier10.3390/v14081692
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873712
dc.descriptionAnnual vaccination against influenza is the best tool to prevent deaths and hospitalizations. Regular updates of trivalent inactivated influenza vaccines (TIV) are necessary due to high mutation rates in influenza viruses. TIV effectiveness is affected by antigenic mismatches, age, previous immunity, and other host factors. Studying TIV effectiveness annually in different populations is critical. The serological responses to Southern-Hemisphere TIV and circulating influenza strains were evaluated in 2018–2020 among Brazilian volunteers, using hemagglutination inhibition (HI) assays. Post-vaccination titers were corrected to account for pre-vaccination titers. Our population achieved >83% post-vaccination seroprotection levels, whereas seroconversion rates ranged from 10% to 46%. TIV significantly enhanced antibody titers and seroprotection against all prior and contemporary vaccine and circulating strains tested. Strong cross-reactive responses were detected, especially between H1N1 subtypes. A/Singapore/INFIMH-16-0019/2016, included in the 2018 TIV, induced the poorest response. Significant titer and seroprotection reductions were observed 6 and 12 months after vaccination. Age had a slight effect on TIV response, whereas previous vaccination was associated with lower seroconversion rates and titers. Despite this, TIV induced high seroprotection for all strains, in all groups. Regular TIV evaluations, based on regional influenza strain circulation, should be conducted and the factors affecting response studied.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectGripe
dc.subjectVacina
dc.subjectImunogenicidade
dc.subjectSoroproteção
dc.subjectSoroconversão
dc.subjectBrasil
dc.subjectInfluenza
dc.subjectVaccine
dc.subjectImmunogenicity
dc.subjectSeroprotection
dc.subjectSeroconversion
dc.subjectBrazil
dc.titleAnalysis of Viral and Host Factors on Immunogenicity of 2018, 2019, and 2020 Southern Hemisphere Seasonal Trivalent Inactivated Influenza Vaccine in Adults in Brazil
dc.typeArticle


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