Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques

dc.creatorFernandes, Rosilainy Surubi
dc.creatorDavid, Mariana Rocha
dc.creatorAbreu, Filipe Vieira Santos de
dc.creatorBrito, Anielly Ferreira de
dc.creatorGardinali, Noemi R.
dc.creatorLIma, Sheila Maria Barbosa
dc.creatorAndrade, Márcia Cristina Ribeiro
dc.creatorKugelmeier, Tatiana
dc.creatorOliveira, Jaqueline Mendes de
dc.creatorPinto, Marcelo A.
dc.creatorOliveira, Ricardo Lourenço de
dc.date2021-01-07T20:41:51Z
dc.date2021-01-07T20:41:51Z
dc.date2020
dc.date.accessioned2023-09-26T21:48:34Z
dc.date.available2023-09-26T21:48:34Z
dc.identifierFERNANDES, Rosilainy Surubi et al. Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques. Viruses, v. 12, 1345, 12p, Nov. 2020.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45536
dc.identifier10.3390/v12121345
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873669
dc.descriptionDespite worldwide e orts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhesus macaques at several time points, half of which were treated with Sofosbuvir (SOF). Mosquitoes were analyzed for vector competence after 3, 7 and 14 days of incubation. Although viremia extended up to eight days post monkey inoculation, only mosquitoes fed on the day of the peak of viremia, recorded on day two, became infected. The influence of SOF treatment could not be assessed because the drug was administered just after mosquito feeding on day two. The global infection, dissemination and transmission rates were quite low (4.09%, 1.91% and 0.54%, respectively); no mosquito was infected when viremia was below 1.26 105 RNA copies/mL. In conclusion, Ae. aegypti vector competence for ZIKV from macaques is low, likely to be due to low viral load and the short duration of ZIKV viremia in primates suitable for infecting susceptible mosquitoes. If ZIKV infection in human and macaques behaves similarly, transmission of the Zika virus in nature is most strongly a ected by vector density.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectZika
dc.subjectPrimatas não humanos
dc.subjectMacacos rhesus
dc.subjectViremia
dc.subjectCapacidade vetorial
dc.subjectTransmissão
dc.subjectNon-human primates
dc.subjectRhesus macaques
dc.subjectZika
dc.subjectViremia
dc.subjectVectorial capacity
dc.subjectTransmission
dc.titleLow Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
dc.typeArticle


Este ítem pertenece a la siguiente institución