Genetic divergence between two sympatric species of the Lutzomyia longipalpis complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production

dc.creatorLins, R. M. M. A.
dc.creatorSouza, N. A.
dc.creatorPeixoto, A. A.
dc.date2019-03-07T11:01:56Z
dc.date2019-03-07T11:01:56Z
dc.date2008
dc.date.accessioned2023-09-26T21:48:24Z
dc.date.available2023-09-26T21:48:24Z
dc.identifierLINS, R. M. M. A.; SOUZA, N. A.; PEIXOTO, A. A. Genetic divergence between two sympatric species of the Lutzomyia longipalpis complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production. Mem. Inst. Oswaldo Cruz, v.103, n.7, p.736-740, Nov. 2008.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31957
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873659
dc.descriptionThe sandfly Lutzomyia longipalpis s.l. is the main vector of American Visceral Leishmaniasis. L. longipalpis s.l. is a species complex but until recently the existence of cryptic sibling species among Brazilian populations was a controversial issue. A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila, was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil. The results revealed para as the first single locus DNA marker presenting fixed differences between the two species in this locality. In addition, two low frequency amino-acid changes in an otherwise very conserved region of the channel were observed, raising the possibility that it might be associated with incipient resistance in this vector. To the best of our knowledge, the present study represents the first population genetics analysis of insecticide resistance genes in this important leishmaniasis vector.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectLutzomyia longipalpis
dc.subjectDrosophila
dc.subjectLeishmaniose
dc.subjectSimpatria
dc.subjectResistência a Inseticidas
dc.subjectPsychodidae
dc.subjectLutzomyia longipalpis
dc.subjectDrosophila
dc.subjectpara
dc.subjectInsecticide resistance
dc.subjectLeishmaniasis
dc.subjectSandflies
dc.subjectSympatric species
dc.subjectSimpatria
dc.titleGenetic divergence between two sympatric species of the Lutzomyia longipalpis complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production
dc.typeArticle


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