Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection

dc.creatorCalabrese, K. S.
dc.creatorSilva, L. S.
dc.creatorHardoim, D. J.
dc.creatorSouza, C. S. F.
dc.creatorSilva, A. L. Abreu
dc.date2015-10-08T23:45:13Z
dc.date2015-10-08T23:45:13Z
dc.date2013
dc.date.accessioned2023-09-26T21:47:40Z
dc.date.available2023-09-26T21:47:40Z
dc.identifierCALABRESE, K. S. et al. Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection. Experimental Parasitology, v.133, n.2, p.156-161, 2013.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11924
dc.identifier10.1016/j.exppara.2012.11.008
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873615
dc.descriptionThere are few studies on human ocular leishmaniasis found in the literature. The purpose of this study was to describe experimental ocular leishmaniasis, caused by Leishmania amazonensis evaluating two different infection routes: intravitreal and instillation in C57BL/10 and BALB/c mice. In this work all animals presented low anti-Leishmania IgM and IgG titers regardless of the infection route or mouse strain. The histopathological eye analysis showed that the mice inoculated by the intravitreal route developed more severe lesions, presenting parasites in the anterior region of the eye 60 days after infection. The C57BL/10 mice presented cells containing parasitophorous vacuoles associated with pigmented cells and inflammatory infiltrate, which included mast cells. Ninety days after infection no parasites could be found in either mouse strain, which led us to hypothesize that parasites had been eliminated. In this context, we show that both intravitreal and instillation routes were effective in promoting ocular leishmaniasis infections in C57BL/10 and BALB/c mice. There were no differences in the parasite infection between the two mouse models and it mimicked the ocular lesions described in symptomatic dogs in endemic areas of visceral leishmaniasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeishmaniasis
dc.subjectEye
dc.subjectMice
dc.subjectLeishmania amazonensis
dc.subjectExperimental model
dc.subjectCamundongos
dc.subjectOlho
dc.subjectLeishmaniose
dc.titleOcular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection
dc.typeArticle


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