Putative mobilized colistin resistance genes in the human gut microbiome

dc.creatorAndrade, Bruno G. N.
dc.creatorGoris, Tobias
dc.creatorAfli, Haithem
dc.creatorCoutinho, Felipe H.
dc.creatorDávila, Alberto M. R.
dc.creatorCuadrat, Rafael R. C.
dc.date2021-07-29T14:43:53Z
dc.date2021-07-29T14:43:53Z
dc.date2021
dc.date.accessioned2023-09-26T21:47:07Z
dc.date.available2023-09-26T21:47:07Z
dc.identifierANDRADE, Bruno G. N. et al. Putative mobilized colistin resistance genes in the human gut microbiome. BMC Microbiology, v. 21, n. 220, 10 p, 2021.
dc.identifier1471-2180
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48406
dc.identifier10.1186/s12866-021-02281-4
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873583
dc.descriptionThe high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin, caused by mobilized colistin resistance (mcr) genes, poses an unprecedented threat to human health. Understanding the spread, evolution, and distribution of such genes among human populations will help in the development of strategies to diminish their occurrence. To tackle this problem, we investigated the distribution and prevalence of potential mcr genes in the human gut microbiome using a set of bioinformatics tools to screen the Unified Human Gastrointestinal Genome (UHGG) collection for the presence, synteny and phylogeny of putative mcr genes, and co-located antibiotic resistance genes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectColistina
dc.subjectMicrobioma humano
dc.subjectMetagenômica
dc.subjectGenes de resistência a antibióticos
dc.subjectColistin
dc.subjectHuman microbiome
dc.subjectMCR
dc.subjectMetagenomics
dc.subjectAntibiotic resistance genes
dc.titlePutative mobilized colistin resistance genes in the human gut microbiome
dc.typeArticle


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