Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors

dc.creatorBraggio, Esteban
dc.creatorBraggio, Danielle de Almeida
dc.creatorSmall, Isabele Ávila
dc.creatorLopes, Lisandro F.
dc.creatorValadão, Marcus
dc.creatorGouveia, Maria Emmerick
dc.creatorMoreira, Aline dos Santos
dc.creatorLinhares, Eduardo
dc.creatorRomano, Sérgio
dc.creatorBacchi, Carlos E.
dc.creatorRenault, Ilana Zalcherg
dc.creatorGuimarães, Denise Peixoto
dc.creatorFerreira, Carlos Gil
dc.date2018-12-08T20:04:17Z
dc.date2018-12-08T20:04:17Z
dc.date2010
dc.date.accessioned2023-09-26T21:47:05Z
dc.date.available2023-09-26T21:47:05Z
dc.identifierBRAGGIO, Esteban; et al. Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors. Anticancer Research, v.30, p.2407-2414, 2010.
dc.identifier0250-7005
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30442
dc.identifier1791-7530
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873581
dc.descriptionBackground: Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). Patients and Methods: Fifty-five Brazilian patients with completely resected GIST were examined for KIT and PDGFRA mutations. The 5-year disease-free survival (DFS) was analyzed. Results: KIT and PDGFRA mutations were identified in 74.5% and 7.3% of patients, respectively. The 5-year DFS rate for all patients was 52.8%. The 5-year DFS rate was lower in patients with tumors having inframe deletions or concomitant in-frame deletions and insertions affecting codons 557-558 than in patients with tumors having other exon 11 KIT mutations (p=0.023). Conversely, when the patients with concomitant deletioninsertion mutations affecting codons 557-558 were excluded from the analysis, deletions involving codons 557-558 had no influence on 5-year DFS rates. Conclusion: Our findings indicate that a specific KIT mutation may be associated with unfavorable behavior in GIST. This finding may have implications on selecting patients for adjuvant therapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Institute of Anticancer Research
dc.rightsopen access
dc.subjectRelevância prognóstica
dc.subjecttumores estromais gastrointestinais
dc.subjectmutações do KIT e PDGFRA
dc.subjectGastrointestinal Stromal Tumors
dc.subjectmutations
dc.subjectPrognostic Relevance
dc.subjectKIT and PDGFRA mutations
dc.titlePrognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors
dc.typeArticle


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