Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city

dc.creatorBouzas, Maiara Lanna Souza Bacelar
dc.creatorOliveira, Juliana R
dc.creatorFukutani, Kiyoshi Ferreira
dc.creatorBorges, Igor Carmo
dc.creatorBarral, Aldina Maria Prado
dc.creatorGucht, Winke Van der
dc.creatorWollants, Elke
dc.creatorVan Ranst, Marc
dc.creatorOliveira, Camila Indiani de
dc.creatorVan Weyenbergh, Johan Jozef Rosa Maria
dc.creatorCarvalho, Cristiana Maria Costa Nascimento
dc.creatorThe Acute Respiratory Infection, Wheeze Study Group Phase I, II
dc.date2017-03-17T14:22:59Z
dc.date2017-03-17T14:22:59Z
dc.date2016
dc.date.accessioned2023-09-26T21:46:12Z
dc.date.available2023-09-26T21:46:12Z
dc.identifierBOUZAS, M. L. S. B. et al. Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city. Medicine, v. 95, p. 41, 2016.
dc.identifier0025-7974
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18072
dc.identifier10.1097/MD.0000000000005142
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873531
dc.descriptionBahia State Agency for Research Funding (FAPESB) [grant numbers APP0045/2009 and PNX0019/2009]. FAPESB had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
dc.descriptionRespiratory syncytial virus (RSV) is one of the most common etiological agents of childhood respiratory infections globally. Information on seasonality of different antigenic groups is scarce. We aimed to describe the frequency, seasonality, and age of children infected by RSV antigenic groups A (RSVA) and B (RSVB) among children with ARI in a 4-year period.Children (6-23 months old) with respiratory infection for ≤7 days were enrolled in a prospective cross-sectional study, from September, 2009 to October, 2013, in Salvador, in a tropical region of Brazil. Upon recruitment, demographic, clinical data, and nasopharyngeal aspirates (NPA) were collected. A multiplex quantitative real-time polymerase chain reaction (RT-PCR) with a group-specific primer and probeset for RSVA and RSVB was used. Seasonal distribution of infection by RSV different antigenic groups was evaluated by Prais-Wisten regression.Of 560 cases, the mean age was 11.4 ± 4.5 months and there were 287 (51.3%) girls. Overall, RSV was detected in 139 (24.8%; 95% CI: 21.4%-28.5%) cases, RSVA in 74 (13.2%; 95% CI: 10.6%-16.2%) cases, and RSVB in 67 (12.0%; 95% CI: 9.5%-14.9%) cases. Two (0.4%; 95% CI: 0.06%-1.2%) cases had coinfection. RSVA frequency was 9.6%, 18.4%, 21.6%, and 3.1% in 2010, 2011, 2012, and 2013, respectively. RSVB frequency was 19.2%, 0.7%, 1.4%, and 35.4% in the same years. RSVA was more frequently found from August to January than February to July (18.2% vs. 6.4%, P < 0.001). RSVB was more frequently found (P < 0.001) between March and June (36.0%) than July to October (1.0%) or November to February (1.6%). RSVB infection showed seasonal distribution and positive association with humidity (P = 0.02) whereas RSVA did not. RSVA was more common among children ≥1-year-old (17.8% vs. 1.8%; P = 0.02), as opposed to RSVB (11.5% vs. 12.2%; P = 0.8).One quarter of patients had RSV infection. RSVA compromised more frequently children aged ≥1 year. RSVA predominated in 2011 and 2012 whereas RSVB predominated in 2010 and 2013. In regard to months, RSVA was more frequent from August to January whereas RSVB was more often detected between March and June. Markedly different monthly as well as yearly patterns for RSVA and RSVB reveal independent RSV antigenic groups' epidemics.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWillams & Wilkins
dc.rightsopen access
dc.subjectInfecção respiratória aguda
dc.subjectImunoprofilaxia
dc.subjectRSV
dc.subjectRSVA
dc.subjectRSVB
dc.subjectSazonalidade
dc.subjectAcute respiratory infection
dc.subjectImmunoprophylaxis
dc.subjectPalivizumab
dc.subjectRSV
dc.subjectRSVA
dc.subjectRSVB
dc.subjectSeasonality
dc.titleRespiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
dc.typeArticle


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