Pathogenesis of pipe-stem fibrosis of the liver (experimental observation on murine schistosomiasis).

dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-23T21:09:38Z
dc.date2012-10-23T21:09:38Z
dc.date1987
dc.date.accessioned2023-09-26T21:44:59Z
dc.date.available2023-09-26T21:44:59Z
dc.identifierANDRADE, Zilton de Araújo. Pathogenesis of pipe-stem fibrosis of the liver (experimental observation on murine schistosomiasis). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 82, n. 3, p. 325-34, jul./set. 1987.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5731
dc.identifier10.1590/s0074-02761987000300003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873461
dc.descriptionMice infected with 30 cercariae of Schistosoma mansoni developed portal and septal fibrosis due to the massive and concentrated deposition of eggs in the periportal areas which occurred following the 16th week after infection. The lesion resembled pipe-stem fibrosis seen in human hepatosplenic schistosomiasis in the following characters: portal fibrosis interconnecting portal spaces as well as portal spaces and central canals; portal inflammation; periovular granulomas; vascular obstruction and telangiectasia. The liver parenchyma maintained its normal architecture. Vascular injection techniques with Indian ink and vinylite revealed that the portal system developed numerous dilated collateral venules coming from the large and medium-sized portal branches, about 10 weeks after schistosome infection. The lodging of schistosome eggs into these collaterals resulted in granulomatous inflammation and fibrosis along all the portal tracts, thus forming the pipe-stem lesion. Although not readily demonstrable grossly, the pipe-stem fibrosis of murine schistosomiasis has many similarities with the human lesion and can be considered to have the same basic pathogenesis.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosomiasis
dc.subjectPipe-stem fibrosis
dc.subjectPathogenesis
dc.subjectCirrose Hepática Experimental/etiologia
dc.subjectHepatopatias Parasitárias/etiologia
dc.subjectSistema Porta
dc.subjectEsquistossomose mansoni/complicações
dc.subjectAnimais
dc.subjectColágeno/metabolismo
dc.subjectFeminino
dc.subjectCirrose Hepática Experimental/patologia
dc.subjectHepatopatias Parasitárias/patologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectEsquistossomose mansoni/patologia
dc.subjectDoenças Vasculares/parasitologia
dc.subjectDoenças Vasculares/patologia
dc.titlePathogenesis of pipe-stem fibrosis of the liver (experimental observation on murine schistosomiasis).
dc.typeArticle


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