Changes in protein expression due to deleterious mutations in the FA/BRCA pathway

dc.creatorSalles, Daniela
dc.creatorCabral, Rosa Estela Caseira
dc.creatorPaixão, Júlio César da
dc.creatorAlmeida, Carlos Eduardo Bonacossa de
dc.creatorSeuánez, Héctor N.
dc.creatorCabral-Neto, Januario Bispo
dc.date2010-08-23T16:00:32Z
dc.date2010-08-23T16:00:32Z
dc.date2007
dc.date.accessioned2023-09-26T21:44:29Z
dc.date.available2023-09-26T21:44:29Z
dc.identifierSALLES, Daniela et al. Changes in protein expression due to deleterious mutations in the FA/BRCA pathway. Biochem. Biophys. Res. Commun, New York, v. 364, n. 4, p. 755-760, Dec. 2007.
dc.identifier0006-291X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/407
dc.identifier10.1016/j.bbrc.2007.10.025
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873432
dc.descriptionInherited deleterious mutations in one of the Fanconi anemia genes lead to a disease, characterized by bone marrow failure, myeloid leukemia, and hypersensitivity to DNA damage. We identified proteins likely associated to the molecular signaling pathways involved in DNA repair of interstrand cross-link lesions and in mechanisms of genomic stability mediated by FA/BRCA pathways. We compared protein maps resolved by bidimensional electrophoresis and analyzed differentially expressed proteins, by mass spectrometry, between FA complementation group C (FANCC)-deficient cells, and their ectopically corrected counterpart in physiological conditions or after treatment with MMC. We found six differentially expressed proteins; among them, the checkpoint mediator protein MDC1 whose expression was disrupted in FANCC/cells. The potential role of differentially expressed proteins in FA phenotype is discussed.
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectDNA Repair
dc.subjectDNA Damage Checkpoint
dc.subjectProtein Expression
dc.subjectGenome Stability
dc.subjectProteína BRCA2 - genética
dc.subjectAnemia de Fanconi - genética
dc.subjectProteína do Grupo de Complementação C da Anemia de Fanconi - genética
dc.subjectProteínas de Grupos de Complementação da Anemia de Fanconi - genética
dc.subjectRegulação da Expressão Gênica - genética
dc.subjectProteínas Nucleares - genética
dc.subjectTransdução de Sinal - genética
dc.subjectTransativadores - genética
dc.titleChanges in protein expression due to deleterious mutations in the FA/BRCA pathway
dc.typeArticle


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