Neuropilin-1 is not a marker of human Foxp3+ Treg

dc.creatorMilpied, Pierre
dc.creatorRenand, Amédée
dc.creatorBruneau, Julie
dc.creatorMendes-da-Cruz, Daniella A.
dc.creatorJacquelin, Sébastien
dc.creatorAsnafi, Vahid
dc.creatorRubio, Marie-Thérèse
dc.creatorMacIntyre, Elizabeth
dc.creatorLepelletier, Yves
dc.creatorHermine, Olivier
dc.date2018-08-16T15:58:57Z
dc.date2018-08-16T15:58:57Z
dc.date2009
dc.date.accessioned2023-09-26T21:37:51Z
dc.date.available2023-09-26T21:37:51Z
dc.identifierMILPIED, Pierre et al. Neuropilin-1 is not a marker of human Foxp31 Treg. European Journal of Immunology, v. 39, p. 1466-1471, 2009.
dc.identifier0014-2980
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28189
dc.identifier10.1002/eji.200839040
dc.identifier1521-4141
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873058
dc.descriptionTreg are immune cells that play a critical role in the regulation of the immune response. Although the transcription factor Foxp3 is widely accepted as the standard marker of Treg, specific surface markers are needed to better characterize these cells and decipher their mechanisms of action. Neuropilin-1 (Nrp-1), a membrane protein primarily involved in the nervous system, was identified as a specific marker of murine Treg, but its expression has not been rigorously investigated in human Treg. Here we show that in contrast to murine Treg and regardless of their origins (blood, thymus, spleen, lymph node or tonsil), human Foxp3(+) Treg do not specifically express Nrp-1. However, a population of Foxp3(-) Nrp-1(+) T cells can be detected in human secondary lymphoid organs, and Nrp-1 expression is induced on peripheral blood T lymphocytes upon in vitro activation. We conclude that Nrp-1 cannot be used as a specific marker of human Treg, but might represent a novel activation marker of human T cells both in vitro and in vivo.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectCamundongo
dc.subjectImunofilinas
dc.subjectHumanos
dc.subjectLinfócitos T Reguladores
dc.subjectÓrgãos linfóides
dc.subjectHuman
dc.subjectLymphoid organs
dc.subjectMouse
dc.subjectNeurophilin-1
dc.subjectTreg
dc.titleNeuropilin-1 is not a marker of human Foxp3+ Treg
dc.typeArticle


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