Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients

dc.creatorCosta, Ronaldo P
dc.creatorGollob, Kenneth J
dc.creatorMachado, Paulo Roberto
dc.creatorBacellar, Maria Olívia Amado Ramos
dc.creatorAlmeida, Roque Pacheco de
dc.creatorBarral, Aldina Maria Prado
dc.creatorBarral Netto, Manoel
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorDutra, Walderez Ornelas
dc.date2014-03-21T18:59:46Z
dc.date2014-03-21T18:59:46Z
dc.date2003
dc.date.accessioned2023-09-26T21:36:37Z
dc.date.available2023-09-26T21:36:37Z
dc.identifierCOSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003.
dc.identifier0165-2478
dc.identifier10.1016/j.imlet.2003.09.001
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7436
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872987
dc.descriptionAdhesion molecules play a crucial role in cell migration and recruitment. Expression of adhesion molecules that preferentially address cells to inflammatory sites is a critical event in the formation and maintenance of leishmaniasis lesions. In this work, we analyzed the expression of CD11a, CD11b and CD62L, adhesion molecules involved in cell activation and circulation, in CD4+ and CD8+ T cells from peripheral blood and lymph nodes of patients with early cutaneous leishmaniasis. The percentage of expression of CD62L, CD11a and CD11b in total lymphocytes was lower in lymph nodes as compared to peripheral blood. Moreover, differences in adhesion molecule expression between blood and lymph nodes were more striking in CD4+ than CD8+ T cells. Stimulation of PBMC from leishmaniasis patients with soluble Leishmania antigens (SLA) lead to the expansion of CD4+CD62Lhigh cells, CD4+CD11b+ cells and to an increase in the intensity of expression of CD11a in CD4+, but not CD8+ T cells. Our data suggest that early activation events that occur in the lymph nodes of patients recently infected with Leishmania lead to changes in T cell adhesion molecule expression, favoring migration to the periphery and increasing the likelihood of further recruitment to lesion sites.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier B.V
dc.rightsopen access
dc.subjectLeishmaniasis
dc.subjectAdhesion molecules
dc.subjectLymph node
dc.subjectLymphocytes
dc.subjectPeripheral blood
dc.subjectLinfócitos T CD4-Positivos/imunologia
dc.subjectMoléculas de Adesão Celular/metabolismo
dc.subjectLeishmaniose Cutânea/sangue
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectLinfonodos/imunologia
dc.subjectAtivação Linfocitária
dc.subjectAnimais
dc.subjectAntígenos CD/análise
dc.subjectAntígenos CD/imunologia
dc.subjectAntígenos de Protozoários/imunologia
dc.subjectLinfócitos T CD8-Positivos/imunologia
dc.subjectHumanos
dc.subjectImunofenotipagem
dc.subjectLeishmania/imunologia
dc.subjectLinfonodos/citologia
dc.titleAdhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
dc.typeArticle


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