Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes

dc.creatorNardy, Ana Flávia F. R.
dc.creatorSilva Filho, João Luiz da
dc.creatorPérez, Ana Rosa
dc.creatorMeis, Juliana de
dc.creatorOliveira, Désio Aurélio Farias de
dc.creatorPenha, Luciana
dc.creatorOliveira, Isadora de Araújo
dc.creatorDias, Wagner B.
dc.creatorTodeschini, Adriane R.
dc.creatorLima, Celio Geraldo Freire de
dc.creatorBellio, Maria
dc.creatorNeves, Celso Caruso
dc.creatorPinheiro, Ana Acácia
dc.creatorTakiya, Christina Maeda
dc.creatorBottasso, Oscar
dc.creatorSavino, Wilson
dc.creatorMorrot, Alexandre
dc.date2016-02-07T21:38:09Z
dc.date2016-02-07T21:38:09Z
dc.date2013
dc.date.accessioned2023-09-26T21:35:04Z
dc.date.available2023-09-26T21:35:04Z
dc.identifierNARDY, Ana Flávia F. R. et al. Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes and Infection, v. 15, p.365e374, 2013.
dc.identifier1286-4579
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12708
dc.identifier10.1016/j.micinf.2013.02.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872897
dc.descriptionIn experimental Trypanosoma cruzi infections, severe thymic atrophy leads to release of activated CD4 þ CD8 þ double-positive (DP) T cells to the periphery. In humans, activated DP T cells are found in the blood in association with severe cardiac forms of human chronic Chagas disease. The mechanisms underlying the premature thymocyte release during the chagasic thymic atrophy remain elusive. We tested whether the migratory properties of intrathymic thymocytes are modulated by the parasite trans-sialidase (TS). We found that TS affected the dynamics of thymocytes undergoing intrathymic maturation, and these changes were accompanied by an increase in the number of recent DP thymic emigrants in the peripheral lymphoid organs. We demonstrated that increased percentages of blood DP T cell subsets were associated with augmented antibody titers against TS in chagasic patients with chronic cardiomyopathy. In vitro studies showed that TS was able to activate the MAPK pathway and actin filament mobilization in thymocytes. These effects were correlated with its ability to modulate the adhesion of thymocytes to thymic epithelial cells and their migration toward extracellular matrix. These findings point to effects of TS that could influence the escape of immature thymocytes in Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectThymocyte
dc.subjectChagas Disease
dc.subjectTrypanosoma cruzi
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectMovimento Celular
dc.titleTrans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes
dc.typeArticle


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