Correction to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients

dc.creatorBoniatti, Janine
dc.creatorTappin, Marcelo R. R.
dc.creatorTeixeira, Rafaela G. da S.
dc.creatorGandos, Tamires A. V.
dc.creatorRios, Luis P. S.
dc.creatorFerreira, Izabelle A. M.
dc.creatorOliveira, Karina C.
dc.creatorCalil-Elias, Sabrina
dc.creatorSantana, Aila K. M.
dc.creatorFonseca, Laís B. da
dc.creatorShimizu, Flavio M.
dc.creatorCarr, Olívia
dc.creatorOliveira Jr, Osvaldo N.
dc.creatorDantas, Fabio M. L.
dc.creatorAmendoeira, Fabio C.
dc.creatorViçosa, Alessandra L .
dc.date2022-05-03T19:30:36Z
dc.date2022-05-03T19:30:36Z
dc.date2022
dc.date.accessioned2023-09-26T21:33:18Z
dc.date.available2023-09-26T21:33:18Z
dc.identifierBoniatti, Janine. et al. In vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients. AAPS PharmSciTech v. 23, n. 22, 2022.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/52521
dc.identifier10.1208/s12249-022-02216-w
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872798
dc.descriptionThe authors are grateful for the fnancial support by PAPES VII, PROEP/FAR/CNPq/Fiocruz, CNPQ, and FAPESP (2018/22214-6). Also, we would like to thank Luciano Simoes Pereirafor all support with the image treatment and the recirculation system construction. The authors also thank Angelo L. Gobbi and Maria H. O. Piazzetta for their technical assistance in the microfabrication laboratory (LMF/LNNano/CNPEM).
dc.descriptionThe assessment of drug taste is crucial for pediatric treatments so that formulations can be developed to enhance their efectiveness. In this study, in vivo and in vitro methods were applied to evaluate the taste of tablets of three drugs administered to children without taste-masking excipients to treat tropical diseases, namely artesunate-mefoquine (ASMQ), praziquantel (PZQ), and benznidazole (BNZ). In the frst method, a model of rat palatability was adapted with recirculation to ensure sample dispersion, and the data were analyzed using ANOVA (single factor, 95%). The taste assessment results (in vivo) indicated an aversion to the three medicines, denoted by the animals retracting themselves to the bottom of the box after the frst contact with the drugs. For the placebo samples, the animals behaved normally, indicating that taste perception was acceptable. The second method was based on the in vitro analysis of capacitance data from a homemade impedimetric electronic tongue. Consistent with the in vivo taste assessment results, the data points obtained with PZQ, ASMQ, and BNZ were far away from those of their placebos in a map built with the multidimensional projection technique referred to as Interactive Document Mapping (IDMAP). A combined analysis of the results with the two methods allowed us to confrm the bitterness of the three drugs, also pointing to electronic tongues as a promising tool to replace in vivo palatability tests.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAAPS PharmSciTech
dc.rightsopen access
dc.subjectOf-label use
dc.subjectPediatric treatment
dc.subjectElectronic tongue
dc.subjectModifed taste aversion model
dc.subjectArtesunate-mefoquine
dc.subjectBenznidazole
dc.titleCorrection to: in vivo and in vitro taste assessment of artesunate-mefloquine, praziquantel, and benznidazole drugs for neglected tropical diseases and pediatric patients
dc.typeArticle


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