Involvement of lectin pathway activation in the complement killing of Giardia intestinalis

dc.creatorEvans-Osses, Ingrid
dc.creatorAnsa-Addo, Ephraim A.
dc.creatorInal, Jameel M.
dc.creatorRamirez, Marcel I.
dc.date2017-09-12T17:25:12Z
dc.date2017-09-12T17:25:12Z
dc.date2010
dc.date.accessioned2023-09-26T21:33:08Z
dc.date.available2023-09-26T21:33:08Z
dc.identifierEVAN-OSSES, Ingrid; et al. Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochemical and Biophysical Research Communications, v.395, p.382–386, 2010.
dc.identifier0006-291X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20979
dc.identifier10.1016/j.bbrc.2010.04.025
dc.identifier1090-2104
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872788
dc.descriptionGiardia intestinalis (syn. G. lamblia, G. duodenalis) is a flagellated unicellular eukaryotic microorganism that commonly causes diarrheal disease throughout the world. In humans, the clinical effects of Giardia infection range from the asymptomatic carrier state to a severe malabsorption syndrome possibly due to different virulence of the Giardia strain, the number of cysts ingested, the age of the host, and the state of the host immune system at the time of infection. The question about how G. intestinalis is controlled by the organism remains unanswered. Here, we investigated the role of the complement system and in particular, the lectin pathway during Giardia infections. We present the first evidence that G. intestinalis activate the complement lectin pathway and in doing so participate in eradication of the parasite. We detected rapid binding of mannan-binding lectin, H-ficolin and L-ficolin to the surface of G. intestinalis trophozoites and normal human serum depleted of these molecules failed to kill the parasites. Our finding provides insight into the role of lectin pathway in the control of G. intestinalis and about the nature of surface components of parasite.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectGiardia lamblia
dc.subjectTrofozoítos
dc.subjectManose
dc.subjectEnteropatias
dc.subjectReceptores de N-Acetilglucosamina
dc.subjectLectina de Ligação
dc.subjectGiardia intestinalis
dc.subjectLectin pathway
dc.subjectTrophozoites
dc.subjectComplement-mediated killing
dc.subjectIntestinal disease
dc.subjectMannose
dc.subjectGlcNAc
dc.titleInvolvement of lectin pathway activation in the complement killing of Giardia intestinalis
dc.typeArticle


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