Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.

dc.creatorAraújo, Alan Moreira de
dc.creatorReis, Eliana Almeida Gomes
dc.creatorAthanazio, Daniel Abensur
dc.creatorRibeiro, Guilherme de Sousa
dc.creatorHagan, José Edward
dc.creatorAraujo, Guilherme C
dc.creatorDamião, Alcinéia Oliveira
dc.creatorCouto, Nicolli S
dc.creatorKo, Albert Icksang
dc.creatorDutra, Alberto Noronha
dc.creatorReis, Mitermayer Galvão dos
dc.date2015-05-25T13:54:00Z
dc.date2015-05-25T13:54:00Z
dc.date2014
dc.date.accessioned2023-09-26T21:32:43Z
dc.date.available2023-09-26T21:32:43Z
dc.identifierARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014.
dc.identifier1476-1645
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10489
dc.identifier10.4269/ajtmh.13-0667
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872765
dc.descriptionLeptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stress
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectLesão Renal Aguda/sangue
dc.subjectGlutationa/sangue
dc.subjectLeptospirose/sangue
dc.subjectEstresse Oxidativo
dc.subjectEspécies de Oxigênio Reativas/sangue
dc.subjectTrombocitopenia/sangue
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectMarcadores Biológicos/sangue
dc.subjectEstudos de Casos e Controles
dc.subjectEstudos de Coortes
dc.subjectCreatinina/sangue
dc.subjectFeminino
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectPotássio/sangue
dc.subjectÍndice de Gravidade de Doença
dc.subjectAdulto Jovem
dc.titleOxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
dc.typeArticle


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