Transcranial Doppler in hemoglobin SC disease

dc.creatorVieira, Camilo
dc.creatorOliveira, Carolina Nogueira Costa de
dc.creatorFigueiredo, Ludmila Araújo Borges de
dc.creatorSantiago, Rayra Pereira
dc.creatorAdanho, Corynne Stephanie Ahouefa
dc.creatorSantana, Sanzio Silva
dc.creatorBurak, Caroline Lang
dc.creatorLyra, Isa Menezes
dc.creatorGoncalves, Marilda Souza
dc.date2017-03-07T16:06:20Z
dc.date2017-03-07T16:06:20Z
dc.date2016
dc.date.accessioned2023-09-26T21:32:27Z
dc.date.available2023-09-26T21:32:27Z
dc.identifierTranscranial Doppler in hemoglobin SC disease. Pediatr Blood & Cancer, p. 1–4, 2016.
dc.identifier1545-5009
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17963
dc.identifier10.1002/pbc.26342
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872750
dc.descriptionStroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler (TCD) flow velocities in hemoglobin SC disease (HbSC). The guidelines for stroke risk are based on evaluations in sickle cell anemia (SCA) or HbS/β thalassemia. Procedure: In this study, we compare cerebral blood flow in patients with SCD stratified by genotypes. A total of 1,664 pediatric patients with SCD underwent TCD velocity screening, and the time-averaged maximum mean velocity (TAMM) was determined in the middle cerebral artery (MCA), anterior cerebral artery (ACA), and distal intracranial internal carotid artery (ICA) . Results: Abnormal velocities were not identified in the ACA; therefore, we only use ICA and MCA velocities. TAMM from the left and right in the ICA andMCA was 134.3 ± 32.0 and 134.4 ± 32.6 cm/s in patients with SCA, and 105.2 ± 20.6 and 104.7 ± 20.0 cm/s in the patients with HbSC, respectively. Mean TAMM between right and left ICA/MCA was 134.5 ± 30.5 cm/s in the SCA group, and 104.9 ± 19.3 cm/s in the HbSC group.Notably, our data show that TCDvelocitieswere significantly lower among the patientswithHbSC compared to SCA. TAMMwas negatively correlated with hemoglobin and hematocrit in both genotypes. Conclusion: These results suggest that a different cut-off value for abnormal TCD velocities could be considered for patients with HbSC. Additional studies are warranted to determine the actual risk of stroke in HbSC genotype associated with this possible TCD risk value.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectHemoglobinopatias
dc.subjectNeurologia e anemia falciforme
dc.subjectDoença falciforme
dc.subjectUltra-som Doppler transcraniano
dc.subjectHemoglobinopathies
dc.subjectNeurology and sickle cell
dc.subjectSickle cell disease
dc.subjectTranscranial Doppler ultrasound
dc.titleTranscranial Doppler in hemoglobin SC disease
dc.typeArticle


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