Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load

dc.creatorPinheiro, Regina Helena Rathsam
dc.creatorBoa-Sorte, Ney
dc.creatorGrassi, Maria Fernanda Rios
dc.creatorCopello, Úrsula Cury
dc.creatorRios, Karla Tayrine Silva Guimarães
dc.creatorAraújo, Thessika
dc.creatorCastro Filho, Bernardo Galvão
dc.date2019-08-07T13:14:53Z
dc.date2019-08-07T13:14:53Z
dc.date2019
dc.date.accessioned2023-09-26T21:30:45Z
dc.date.available2023-09-26T21:30:45Z
dc.identifierPINHEIRO, Regina Helena Rathsam et al. Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load. Brazilian Journal of Infectious Disease, v. 23, n. 2, p. 95-101, 2019.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34646
dc.identifier10.1016/j.bjid.2019.04.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872651
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (301092/2018-4), Fundação de Amparo à Pesquisa do Estado da Bahia (Fapesb)(CNV0072/2013) and Fundação Nacional para o Desenvolvimento do Ensino Superior (Funadesp).
dc.descriptionThe prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohortof HTLV-1-infected individuals living in Salvador, Brazil.Methods: A cross-sectional study was conducted between June 2004 and September 2017 atthe Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from758 HTLV-1-infected patients was collected. A complete ophthalmologic examination wasperformed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengaland Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out ofthree positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regressionwith robust error variance.Results: The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR: 1.84; CI95%:1.50–2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjustedPR: 1.63; CI95%: 1.31–2.02). Proviral load, low corrected visual acuity, burning and/or pain anditching were all significantly higher in patients with KCS.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectHTLV-1
dc.subjectKeratoconjunctivitis sicca
dc.subjectPrevalência
dc.subjectSyndromesa olho seco
dc.subjectHTLV-1
dc.subjectKeratoconjunctivitis sicca
dc.subjectPrevalence
dc.subjectDry eye syndromesa
dc.titleRevisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load
dc.typeArticle


Este ítem pertenece a la siguiente institución