Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorYeum, Kyung-Jin
dc.creatorAhn, Sei-Hyun
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorLee-Kirn, Yang Cha
dc.creatorKrinsky, Norman I.
dc.creatorRussell, Robert M.
dc.date2014-05-27T11:19:37Z
dc.date2016-10-25T18:15:18Z
dc.date2014-05-27T11:19:37Z
dc.date2016-10-25T18:15:18Z
dc.date1998-11-01
dc.date.accessioned2017-04-06T00:52:38Z
dc.date.available2017-04-06T00:52:38Z
dc.identifierJournal of Nutrition, v. 128, n. 11, p. 1920-1926, 1998.
dc.identifier0022-3166
dc.identifierhttp://hdl.handle.net/11449/65540
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65540
dc.identifierWOS:000076881100012
dc.identifier2-s2.0-0031771365
dc.identifierhttp://jn.nutrition.org/content/128/11/1920.long
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/887255
dc.descriptionTo evaluate the relationship between carotenoid concentrations in serum and breast tissue, we measured serum carotenoid concentrations and endogenous carotenoid levels in breast adipose tissue of women with benign breast tumor (n = 46) or breast cancer (n = 44). Before extraction, serum was digested with lipase and cholesterol esterase, and breast adipose tissue was saponified. Serum and tissue carotenoids were extracted with ether/hexane and measured by using HPLC with a C30 column. Serum retinoic acid was extracted with chloroform/methanol and measured using HPLC with a C18 column. There were no significant differences in serum carotenoids [lutein, zeaxanthin, cryptoxanthin (both α- and β-), α-carotene, all-trans β-carotene, 13-cis β-carotene and lycopene], retinoids (retinol, all-trans and 13-cis retinoic acids), and α- and -γ- tocopherol concentrations between benign breast tumor patients and breast cancer patients. A substantial amount of 9-cis β- carotene was present in adipose tissue and was the only carotenoid that had a significantly lower level in benign breast tumor patients than in breast cancer patients. Correlations between carotenoid concentrations in serum and in breast adipose tissue were determined by combining the data of the two groups. Concentrations of the major serum carotenoids except cryptoxanthin showed significant correlations with breast adipose tissue carotenoid levels. When the concentrations of serum carotenoids were adjusted for serum triglycerides or LDL, correlations between serum carotenoid concentrations and breast adipose tissue carotenoid levels markedly increased, including that of cryptoxanthin (P <0.001). The strong correlation between serum carotenoid concentrations and endogenous breast adipose tissue carotenoid levels indicate that dietary intake influences adipose tissue carotenoid levels as well as serum concentrations, and that adipose tissue is a dynamic reservoir of fat-soluble nutrients.
dc.languageeng
dc.relationJournal of Nutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdipose tissue
dc.subjectBreast cancer
dc.subjectCarotenoids
dc.subjectalpha carotene
dc.subjectalpha tocopherol
dc.subjectbeta carotene
dc.subjectcarotenoid
dc.subjectchloroform
dc.subjectcholesterol esterase
dc.subjectcryptoxanthin
dc.subjectether
dc.subjectgamma tocopherol
dc.subjecthexane
dc.subjectisotretinoin
dc.subjectlipid
dc.subjectlow density lipoprotein
dc.subjectlycopene
dc.subjectmethanol
dc.subjectretinoic acid
dc.subjectretinoid
dc.subjectretinol
dc.subjecttocopherol
dc.subjecttriacylglycerol
dc.subjecttriacylglycerol lipase
dc.subjectxanthophyll
dc.subjectzeaxanthin
dc.subjectadipose tissue
dc.subjectbenign tumor
dc.subjectblood level
dc.subjectbreast
dc.subjectbreast cancer
dc.subjectbreast tumor
dc.subjectcontrolled study
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectAdipose Tissue
dc.subjectAdult
dc.subjectbeta Carotene
dc.subjectBreast
dc.subjectBreast Neoplasms
dc.subjectChromatography, High Pressure Liquid
dc.subjectRetinoids
dc.subjectTriglycerides
dc.subjectVitamin E
dc.subjectXanthophylls
dc.titleCorrelation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer
dc.typeOtro


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