Insights into the Cytoadherence Phenomenon of Plasmodium vivax: The Putative Role of Phosphatidylserine

dc.creatorTotino, Paulo Renato
dc.creatorLopes, Stefanie Costa
dc.date2018-02-20T12:05:56Z
dc.date2018-02-20T12:05:56Z
dc.date2017
dc.date.accessioned2023-09-26T21:28:07Z
dc.date.available2023-09-26T21:28:07Z
dc.identifierTOTINO, Paulo Renato; LOPES, Stefanie Costa. Insights into the Cytoadherence Phenomenon of Plasmodium vivax: the Putative Role of Phosphatidylserine. Frontiers in Immunology, v.8, Article 1148, 6p, Sept. 2017.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/24874
dc.identifier10.3389/fimmu.2017.01148
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872502
dc.descriptionPlasmodium vivax is the most geographically widespread and the dominant human malaria parasite in most countries outside of sub-Saharan Africa and, although it was classically recognized to cause benign infection, severe cases and deaths caused byP. vivaxhave remarkably been reported. In contrast toPlasmodium falciparum, which well-known ability to bind to endothelium and placental tissue and form rosettes is related to severity of the disease, it has been a dogma thatP. vivaxis unable to undergo cytoadherent phenomena. However, some studies have demonstrated that red blood cells (RBCs) infected byP. vivaxcan cytoadhere to host cells, while the molecules participating in this host-parasite interaction are still a matter of speculation. In the present overview, we address the evidences currently supporting the adhesive profile ofP. vivaxand, additionally, discuss the putative role of phosphatidylserine-a cell membrane phospholipid with cytoadhesive properties that has been detected on the surface ofPlasmodium-parasitized RBCs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectPlasmodium vivax
dc.subjectcitoplasma
dc.subjecteriptose
dc.subjectrosetaria
dc.subjectfosfatidilserina
dc.subjectMalária
dc.subjectPlasmodium vivax
dc.subjectcytoadhesion
dc.subjectrosetting
dc.subjecteryptosis
dc.subjectphosphatidylserine
dc.subjectmalaria
dc.titleInsights into the Cytoadherence Phenomenon of Plasmodium vivax: The Putative Role of Phosphatidylserine
dc.typeArticle


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