Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice

dc.creatorAlmeida, Roque Pacheco de
dc.creatorBarral Netto, Manoel
dc.creatorJesus, Amélia Maria Ribeiro de
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorBarral, Aldina Maria Prado
dc.date2014-05-13T13:56:28Z
dc.date2014-05-13T13:56:28Z
dc.date1996
dc.date.accessioned2023-09-26T21:23:05Z
dc.date.available2023-09-26T21:23:05Z
dc.identifierALMEIDA, R. P. et al. Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice. American Journal of Tropical Medicine and Hygiene, v. 54, n. 2, p. 178-184, 1996.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7612
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872217
dc.descriptionLeishmania amazonensis causes a wide spectrum of disease in humans. In this study, we evaluated BALB/c mice infected with five strains of L. amazonensis isolated from patients with either cutaneous, mucosal, or visceral leishmaniasis. Mice infected with cutaneous and mucosal isolates developed ulcerating footpad lesions with parasite-loaded macrophages and extensive tissue destruction. Skin métastases,early dissemination of parasites to the spleen, and high anü-Leishmaniaantibody levels were also noted. Mice infected with L. amazonensis strains isolated from patients with visceral disease had a controlled infection, with small footpad lesions with mononuclear cell infiltration, few infected macrophages, and granuloma formation. They had no skin métastases,delayed dissemination of the parasite to the spleen, lower levels of IgG and higher levels of IgG2a against L. amazonensis. These findings demonstrate an unexpected resistance of BALB/c mice to the infection with L. amazonensis isolated from patients with visceral leishmaniasis. This resistance seems to be due to differences in these parasites that may be related to the altered course of the disease in humans and in isogenic BALB/c mice.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectLeishmania/patogenicidade
dc.subjectLeishmaniose Cutânea/parasitologia
dc.subjectLeishmaniose Mucocutânea/parasitologia
dc.subjectLeishmaniose Visceral/parasitologia
dc.subjectAnimais
dc.subjectAnticorpos Antiprotozoários/sangue
dc.subjectFeminino
dc.subjectHumanos
dc.subjectImunoglobulina G/sangue
dc.subjectLeishmania/imunologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.titleBiological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice
dc.typeArticle


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