An updated map of Trypanosoma cruzi histone post-translational modifications

dc.creatorAlmeida, Rafael Fogaça de
dc.creatorFernandes, Matheus
dc.creatorGodoy, Lyris Martins Franco de
dc.date2021-04-22T14:09:15Z
dc.date2021-04-22T14:09:15Z
dc.date2021
dc.date.accessioned2023-09-26T21:22:00Z
dc.date.available2023-09-26T21:22:00Z
dc.identifierALMEIDA, Rafael Fogaça de et al. An updated map of Trypanosoma cruzi histone post-translational modifications. Scientific Data, v.8 n. 93, p. 1–10, 2021.
dc.identifier2052-4463
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46835
dc.identifier10.1038/s41597-021-00818-w
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872154
dc.descriptionIn humans and other eukaryotes, histone post-translational modifcations (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly atthe post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi,the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we applied an optimized mass spectrometry-based proteomic workfow to provide a high-confdence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our work expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates forthe development of epigenetic drugs against trypanosomatids.
dc.formatapplication/pdf
dc.languagepor
dc.publisherNature Research
dc.rightsopen access
dc.subjectEpigenômica
dc.subjectTrypanosoma cruzi
dc.subjectHistones
dc.subjectEpigenomics
dc.subjectEpigenómica
dc.subjectHistone
dc.subjectÉpigénomique
dc.subjectHistonas
dc.subjectEpigenética
dc.titleAn updated map of Trypanosoma cruzi histone post-translational modifications
dc.typeArticle


Este ítem pertenece a la siguiente institución