Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review

dc.creatorAraújo, Paulo S. Ramos de
dc.creatorSilva Júnior, Mário L. de Mélo
dc.creatorTenório, Marli
dc.creatorSantos, Fabiana G. Torreão Dos
dc.date2018-08-01T11:30:27Z
dc.date2018-08-01T11:30:27Z
dc.date2018
dc.date.accessioned2023-09-26T21:19:15Z
dc.date.available2023-09-26T21:19:15Z
dc.identifierARAÚJO, P. S. R. DE et al. Co-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review. Journal of Infection and Public Health, p. 1-4, Apr. 2018.
dc.identifier1876-035X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27750
dc.identifier10.1016/j.jiph.2018.04.010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871998
dc.descriptionA man, 26years-old, presented fever, mental confusion and a progressively worsening headache 6days prior to admission. The CSF study was suggestive of meningoencephalitis, the PCR study revealed presence of HSV-1 and ZIKV, while other immunology tests were negative. ZIKV was also identified in serum. The MRI showed temporal lobe hyper-intensity in FLAIR-weight sequence with areas of contrast enhancement and the electroencephalogram showed slow wave activity in such region. Patient was treated with acyclovir and supportive measures and had good clinical outcome at evaluation after 6 months. Neurological spectrum of ZIKV manifestations is wide, but meningoencephalitis is not frequent. Co-infection HSV-1 plus ZIKV was not yet related in humans, but there is increased cellular damage caused by association of ZIKV and herpes virus family infection. ZIKV may facilitate infection or recrudescence by other viruses or cause concurrently neuronal injury by direct or indirect mechanisms. We suggest that clinicians attempt new manifestations related to ZIKV and include this agent in differential diagnosis of neurological diseases even when other agents were identified.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectVírus Zika
dc.subjectHerpesvírus humano 1
dc.subjectMeningoencefalite
dc.subjectRelato de caso
dc.subjectZika virus
dc.subjectHuman herpesvirus 1
dc.subjectMeningoencephalitis
dc.subjectCase report
dc.subjectMeningoencefalite / diagnóstico
dc.subjectAdulto
dc.subjectZika virus / infecção
dc.subjectZika virus / diagnóstico
dc.subjectHumanos
dc.subjectBrasil / epidemiologia
dc.subjectEstudo de caso
dc.titleCo-infection ZIKV and HSV-1 associated with meningoencephalitis: Case report and literature review
dc.typeArticle


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