The distribution of Campylobacter jejuni virulence genes in genomes worldwide derived from the NCBI pathogen detection database

dc.creatorPanzenhagen, Pedro
dc.creatorPortes, Ana Beatriz
dc.creatorSantos, Anamaria M. P. dos
dc.creatorDuque, Sheila da Silva
dc.creatorConte Junior, Carlos Adam
dc.date2021-11-03T13:25:14Z
dc.date2021-11-03T13:25:14Z
dc.date2021
dc.date.accessioned2023-09-26T21:17:35Z
dc.date.available2023-09-26T21:17:35Z
dc.identifierPANZENHAGEN, Pedro et al. The distribution of Campylobacter jejuni virulence genes in genomes worldwide derived from the NCBI pathogen detection database. Genes, v. 12, n. 10, p. 1-13, 28 Sept. 2021.
dc.identifier2073-4425
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49637
dc.identifier10.3390/genes12101538
dc.identifier2073-4425
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871909
dc.descriptionCampylobacter jejuni (C. jejuni) is responsible for 80% of human campylobacteriosis and is the leading cause of gastroenteritis globally. The relevant public health risks of C. jejuni are caused by particular virulence genes encompassing its virulome. We analyzed 40,371 publicly available genomes of C. jejuni deposited in the NCBI Pathogen Detection Database, combining their epidemiologic metadata with an in silico bioinformatics analysis to increase our current comprehension of their virulome from a global perspective. The collection presented a virulome composed of 126 identified virulence factors that were grouped in three clusters representing the accessory, the softcore, and the essential core genes according to their prevalence within the genomes. The multilocus sequence type distribution in the genomes was also investigated. An unexpected low prevalence of the fulllength flagellin flaA and flaB locus of C. jejuni genomes was revealed, and an essential core virulence gene repertoire prevalent in more than 99.99% of genomes was identified. Altogether, this is a pioneer study regarding Campylobacter jejuni that has compiled a significant amount of data about the Multilocus Sequence Type and virulence factors concerning their global prevalence and distribution over this database.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectDistribuição dos genes de virulência
dc.subjectCampylobacter jejuni
dc.subjectGenomas
dc.subjectDerivados do patógeno NCBI
dc.subjectBanco de dados de detecção
dc.subjectC. jejuni
dc.subjectWGS
dc.subjectflaA
dc.subjectflaB
dc.subjectC. jejuni
dc.subjectWGS
dc.subjectVirulence genes
dc.subjectVirulence factors
dc.subjectMLST
dc.subjectflaA
dc.subjectflaB
dc.titleThe distribution of Campylobacter jejuni virulence genes in genomes worldwide derived from the NCBI pathogen detection database
dc.typeArticle


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