Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.

dc.creatorLenzi, Jane A.
dc.creatorSobral, A. C. L.
dc.creatorAraripe, J. R.
dc.creatorGrimaldi Filho, G.
dc.creatorLenzi, Henrique Leonel
dc.date2012-05-10T14:50:43Z
dc.date2012-05-10T14:50:43Z
dc.date1987
dc.date.accessioned2023-09-26T21:16:20Z
dc.date.available2023-09-26T21:16:20Z
dc.identifierLENZI, J. A. et al. Congenital and nursing effects on the evolution of Schistosoma mansoni infection in mice. Memórias do Instituto Oswaldo Cruz, v.82, sup.4, p. 257-267, 1987.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4055
dc.identifierhttp://dx.doi.org/10.1590/S0074-02761987000800049
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871845
dc.descriptionModification of the immune response to schistosomal infection in children or offspring born to mother R infected with Schistosoma mansoni has been demonstrated in human and in experimental schistosomiasis. One of the hypothesis to explain this fact could be the transfer of circulating antigens and antibodies from mother to foetus through the placenta or from mother to child by milk. The results of this spontaneous transference are controversial in the literature. In an attempt to investigate these questions, we studied one hundred and twenty offspring (Swiss mice), sixty born to infected-mothers (group A) and sixty born to non-infected mothers (group B). These were percutaneously infected with 50 cercariae/mouse, and divided in six sub-groups (20 mice/sub-group), according to the following schedule: after birth (sub-groups A.I and B.I), 10 days old (sub-groups A.II and B.II) and 21 days old (sub-groups A.III and B.III). After the exposure period, the young mice returned to their own mothers for nursing. Six weeks later, the mice were killed. We obtained the following results: 1) There is transference of antibody to cercariae (CAP), adult worms (SWAP) and egg antigens (SEA) from the infected mothers to the offspring, probably through placenta and milk; 2) Offspring born to infected mothers exhibit much less coagulative hepatic necrosis and show a lower number of eggs in the small intestine and a less intense and predominant exsudative stage of the hepatic granulomas when compared with the exsudative-productive stage of the control groups. The findings suggest that congenital and nursing factors can interfere on the development of the schistosomiasis infection, causing an hyporesponse to the eggs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectAntibodies
dc.subjectImmunology
dc.subjectHelminth
dc.subjectMaternal-Fetal Exchange
dc.subjectSchistosomiasis mansoni
dc.subjectPregnancy Complications
dc.subjectAntigens
dc.subjectAnticorpos, imunologia
dc.subjectAntígenos de Helmintos
dc.subjectTroca Materno-Fetal
dc.subjectEsquistossomose mansoni
dc.subjectComplicações na Gravidez
dc.titleCongenital and nursing effects on the evolution of Schistosoma mansoni infection in mice.
dc.typeArticle


Este ítem pertenece a la siguiente institución