Inflammatory cell infiltration and high antibody production in balb/c mice caused by natural exposure to Lutzomyia longipalpis bites

dc.creatorSilva, Francinaldo
dc.creatorGomes, Regis Bernardo Brandim
dc.creatorPrates, Deboraci Brito
dc.creatorMiranda, José Carlos
dc.creatorAndrade, Bruno de Bezerril
dc.creatorBarral Netto, Manoel
dc.creatorBarral, Aldina Maria Prado
dc.date2011-09-14T18:12:44Z
dc.date2011-09-14T18:12:44Z
dc.date2005
dc.date.accessioned2023-09-26T21:16:02Z
dc.date.available2023-09-26T21:16:02Z
dc.identifierSILVA, F. et al. Inflammatory cell infiltration and high antibody production in BALB/c mice caused by natural exposure to Lutzomyia longipalpis bites. American Journal of Tropical Medicine and Hygiene, v.72, n.1, p.94-98, jan. 2005.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3239
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871766
dc.descriptionSand flies inject saliva into the mammalian host when probing for a blood meal. Understanding the initial vertebrate reactions against sand fly saliva is important for possible interventions because these insects transmit diseases to humans and other animals. Little is known of these reactions to New World sand flies. Repeated exposure of BALB/c mice to Lutzomyia longipalpis bites leads to local inflammatory cell infiltration comprised of neutrophils, macrophages, and eosinophils. Total IgG and IgG1 antibodies react predominantly with three major protein bands (45, 44, and 16 kD) of the insect saliva by Western blot. The injection of immune serum previously incubated with salivary gland homogenate induced an early infiltration with neutrophils and macrophages, suggesting the participation of immune complexes in triggering inflammation.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAnticorpos
dc.subjectMordeduras e Picadas de Insetos
dc.subjectMacrófagos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectPsychodidae
dc.subjectSaliva
dc.subjectLinfócitos
dc.subjectAnimais
dc.titleInflammatory cell infiltration and high antibody production in balb/c mice caused by natural exposure to Lutzomyia longipalpis bites
dc.typeArticle


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