Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

dc.creatorBianchi, Martina
dc.creatorBenvenuto, Domenico
dc.creatorGiovanetti, Marta
dc.creatorAngeletti, Silvia
dc.creatorCiccozzi, Massimo
dc.creatorPascarella, Stefano
dc.date2020-07-27T20:51:10Z
dc.date2020-07-27T20:51:10Z
dc.date2020
dc.date.accessioned2023-09-26T21:15:48Z
dc.date.available2023-09-26T21:15:48Z
dc.identifierBIANCHI, Martina et al. Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? Biomed Research International, v. 2020, Article ID 4389089, p. 1-6, 2020.
dc.identifier2314-6133
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42416
dc.identifier10.1155/2020/4389089
dc.identifier2314-6141
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871705
dc.descriptionThe Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectSARS-CoV-2
dc.subjectEnvelope SARS-CoV-2
dc.subjectProteínas de membrana
dc.subjectEstruturais Diferenças
dc.subjectCaracterísticas do vírus
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectEnvelope and Membrane proteins
dc.subjectStructural Differences
dc.subjectVirus Characteristics
dc.subjectCOVID-19
dc.titleSars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
dc.typeArticle


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