Effects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the metabolism of the experimental intermediate host Biomphalaria glabrata

dc.creatorTunholi-Alves, Vinícius Menezes
dc.creatorTunholi, Victor Menezes
dc.creatorPinheiro, Jairo
dc.creatorThiengo, Silvana Carvalho
dc.date2020-04-26T21:23:03Z
dc.date2020-04-26T21:23:03Z
dc.date2012
dc.date.accessioned2023-09-26T21:15:33Z
dc.date.available2023-09-26T21:15:33Z
dc.identifierTUNHOLI-ALVES, Vinícius Menezes et al. Effects of infection byl arvae of Angiostrongylus cantonensis (Nematoda,Metastrongylidae)on th emetabolism of the experimental intermediate host Biomphalaria glabrata. Experimental Parasitology, v. 131, p. 143-147, Mar. 2012.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40974
dc.identifier10.1016/j.exppara.2012.03.003
dc.identifier1090-2449
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871642
dc.descriptionThe effect of infection by Angiostrongylus cantonensis on the activity of the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the concentration of total proteins, uric acid and urea in the hemolymph of Biomphalaria glabrata were investigated. The snails were dissected after 1, 2 and 3 weeks of infection to collect the hemolymph. The infection by A. cantonensis induced severe changes in the host snail's metabolism, triggering physiological mechanisms to minimize the deleterious effects caused by the larvae. There was a significant decrease in the concentration of total proteins in the infected snails, which occurred gradually as the infection advanced. This change was accompanied by an increase in the concentrations of urea and a decrease in the levels of uric acid in the hemolymph, suggesting that in this model the infection induces proteolysis and inversion of the excretion pattern of the infected snails. Besides this, variations in the activities of the aminotransferases were observed, with significantly higher levels in the infected groups than in the control group. These results indicate an increase in the protein metabolism of the infected snails, since there was an increase in nitrogen catabolites such as urea.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectBiomphalaria glabrata
dc.subjectAngiostrongylus cantonensis
dc.subjectMudanças bioquímicas
dc.subjectRelação hospedeira-parasita
dc.subjectHost–parasite relationship
dc.subjectBiomphalaria glabrata
dc.subjectAngiostrongylus cantonensis
dc.subjectBiochemical changes
dc.titleEffects of infection by larvae of Angiostrongylus cantonensis (Nematoda, Metastrongylidae) on the metabolism of the experimental intermediate host Biomphalaria glabrata
dc.typeArticle


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