Tuberculosis Burden and Determinants of Treatment Outcomes 2 According to Age in Brazil: A Nationwide Ecological Study of 896,314 3 Cases Reported Between 2010 and 2019

dc.creatorDuarte, Beatriz Barreto
dc.creatorPereira, Mariana Araújo
dc.creatorNogueira, Betânia M. F.
dc.creatorSobral, Luciana
dc.creatorRodrigues, Moreno M. S.
dc.creatorQueiroz, Artur Trancoso Lopo
dc.creatorRocha, Michael Santos
dc.creatorNascimento, Vanessa
dc.creatorSouza, Alexandra B.
dc.creatorSantos, Marcelo Cordeiro
dc.creatorKritski, Afrânio L.
dc.creatorSterling, Timothy R.
dc.creatorArriaga Gutiérrez, María Belen
dc.creatorAndrade, Bruno de Bezerril
dc.date2021-08-23T12:46:07Z
dc.date2021-08-23T12:46:07Z
dc.date2021
dc.date.accessioned2023-09-26T21:15:32Z
dc.date.available2023-09-26T21:15:32Z
dc.identifierDUARTE, Beatriz Barreto et al. Tuberculosis Burden and Determinants of Treatment Outcomes According to Age in Brazil: A Nationwide Ecological Study of 896,314 Cases Reported Between 2010 and 2019. Frontiers in Medicine, 2021.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48697
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871638
dc.descriptionNational Institutes of Health
dc.descriptionApproximately 1·4 million people die annually worldwide from tuberculosis. Large 42 epidemiologic studies can identify determinants of unfavorable clinical outcomes according to age, 43 which can guide implementation of public health policies and clinical management to improve 44 outcomes. 45 Methods: We obtained data from the national tuberculosis case registry: cases reported to the Brazilian 46 National Program (SINAN) between 2010-2019. Clinical and epidemiologic variables were compared 47 between age groups (child:<10 years, young:10-24years, adult:25-64years and elderly:≥65years). 48 Univariate comparisons were performed together with second-generation p-values. We applied a 49 backward stepwise multivariable logistic regression model to identify characteristics in each age group 50 associated with unfavorable TB treatment outcomes. 51 Findings: There were 896,314 tuberculosis cases reported during the period. The tuberculosis 52 incidence was highest among adult males, but the young males presented the highest growth rate 53 between the period. Directly observed therapy (DOT) was associated with protection against 54 unfavorable outcomes in all age groups. The use of alcohol, illicit drugs, and smoking, as well as 55 occurrence of comorbidities were significantly different between age groups. Lack of DOT, previous 56 tuberculosis, race, location of tuberculosis disease, and HIV infection were independent risk factors 57 for unfavorable outcome depending on the age group. 58 Interpretation: The clinical and epidemiological risk factors for unfavorable tuberculosis treatment 59 outcomes varied according to age in Brazil. DOT was associated with improved outcomes in all age 60 groups. Incidence according to the age and sex identified adults and young males as the groups that 61 need prevention efforts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectTuberculose
dc.subjectIdoso
dc.subjectFatores de risco
dc.subjectGrupos de Populações Continentais
dc.subjectGrupos Etários
dc.subjectTuberculosis
dc.subjectAge
dc.subjectOutcomes
dc.subjectPulmonary TB
dc.subjectExtrapulmonary TB
dc.titleTuberculosis Burden and Determinants of Treatment Outcomes 2 According to Age in Brazil: A Nationwide Ecological Study of 896,314 3 Cases Reported Between 2010 and 2019
dc.typePreprint


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