Brasil | Article

Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration

dc.creatorAlbuquerque, Cassiano Felippe Gonçalves de
dc.creatorBurth, Patrícia
dc.creatorIbrahim, Mauricio Younes
dc.creatorGarcia, Diogo Gomes
dc.creatorBozza, Patrícia Torres
dc.creatorFaria Neto, Hugo Caire Castro
dc.creatorFaria, Mauro Velho Castro
dc.date2017-05-30T11:50:46Z
dc.date2017-05-30T11:50:46Z
dc.date2012
dc.date.accessioned2023-09-26T21:15:32Z
dc.date.available2023-09-26T21:15:32Z
dc.identifierALBUQUERQUE, Cassiano Felipe Gonçalves de; et al. Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury inMice after Intravenous or Enteral Oleic Acid Administration. Mediators and Inflammation, Volume 2012, Article ID 601032, 8p, 2012.
dc.identifier0962-9351
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19054
dc.identifier10.1155/2012/601032
dc.identifier1466-1861
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871637
dc.descriptionAlthough exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. Surprisingly, 24 h after intravenous or intragastric administration of OLA, main NEFA levels (OLA inclusive) were dose dependently decreased. However, lung injury was detected in intravenously treated mice, and highest dose killed all mice. When administered by the enteral route, OLA was not toxic in any tested conditions. Results indicate that OLA has important regulatory properties on fatty acid metabolism, possibly lowering circulating fatty acid through activation of peroxisome proliferator-activated receptors. The significant reduction in blood NEFA levels detected after OLA enteral administration can contribute to the already known health benefits brought about by unsaturated-fatty-acid-enriched diets.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectÁcido oleico
dc.subjectPlasma Reduzido Nonesterificado
dc.subjectácidos graxos
dc.subjectLesão pulmonar aguda
dc.subjectoleic acid
dc.subjectfatty acids
dc.subjectAcute Lung Injury
dc.subjectReduced Plasma Nonesterified
dc.titleReduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration
dc.typeArticle


Este ítem pertenece a la siguiente institución