Influence of HIV Infection on Mortality in a Cohort of Patients Treated for Tuberculosis in the Context of Wide Access to HAART, in Rio de Janeiro, Brazil

dc.creatorSchmaltz, Carolina Arana Stanis
dc.creatorSant`Anna, Flávia Marinho
dc.creatorNeves, Simone Carvalho
dc.creatorVelasque, Luciane de Souza
dc.creatorLourenço, Maria Cristina
dc.creatorMorgado, Mariza Gonçalves
dc.creatorRolla, Valéria Cavalcanti
dc.creatorLopes, Guilherme Santoro
dc.date2017-08-15T14:57:34Z
dc.date2017-08-15T14:57:34Z
dc.date2009
dc.date.accessioned2023-09-26T21:14:10Z
dc.date.available2023-09-26T21:14:10Z
dc.identifierSCHMALTZ, Carolina Arana Stanis et al. Influence of HIV Infection on Mortality in a Cohort of Patients Treated for Tuberculosis in the Context of Wide Access to HAART, in Rio de Janeiro, Brazil. Journal of Acquired Immune Deficiency Syndromes, v. 52, n. 5, p. 623–628, Dec. 2009.
dc.identifier1525-4135
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20621
dc.identifier10.1097/QAI.0b013e3181b31e56
dc.identifier1944-7884
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871272
dc.descriptionObjective: To analyze the influence of HIV serostatus on mortality related to tuberculosis (TB) in the context of wide access to highly active antiretroviral therapy (HAART) in a middle-income country. Methods: Prospective cohort study including patients who started antituberculous therapy between April 2000 and July 2005 at a referral center in Rio de Janeiro, Brazil. Results: Two hundred seven patients were enrolled, 106 were seropositive for HIV. There were 21 TB-related deaths in HIVpositive subjects (24.7 deaths per 100 patient-years) and 2 (2.5 deaths per 100 patient-years) among HIV-negative patients (rate ratio = 9.76, P , 0.001). Among HIV-infected subjects, TB-related mortality tended to be lower in patients treated with HAART [hazard ratio (HR) = 0.58, P = 0.06]. However, mortality among patients treated with HAARTwas still significantly increased as compared with HIVnegative patients (HR = 6.6, P = 0.014). In a Cox regression model adjusted for disseminated TB (P = 0.04), and treatment with antituberculous regimens not containing rifampicin (P = 0.11), mortality was significantly higher among seropositive patients not on HAART compared with HIV-negative subjects (HR = 6.30, P = 0.024). Among subjects treated with HAART, there was a nonsignificant increase in mortality (rate ratio = 3.48, P = 0.14). Conclusions: HIV infection still has a substantial impact on TB-related mortality in the context of wide access to HAART in a middle-income country.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsrestricted access
dc.subjectBrasil
dc.subjectHIV
dc.subjectMortalidade
dc.subjectTuberculose
dc.subjectTerapia Antirretroviral de Alta Atividade
dc.subjectBrazil
dc.subjectHAART
dc.subjectHIV
dc.subjectMortality
dc.subjectTuberculosis
dc.titleInfluence of HIV Infection on Mortality in a Cohort of Patients Treated for Tuberculosis in the Context of Wide Access to HAART, in Rio de Janeiro, Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución