Role of alternative polyadenylation during adipogenic differentiation: an in silico approach

dc.creatorSpangenberg, Lucia
dc.creatorDominguez, Alejandro Correa
dc.creatorDallagiovanna, Bruno
dc.creatorNaya, Hugo
dc.date2016-09-30T17:12:37Z
dc.date2016-09-30T17:12:37Z
dc.date2013
dc.date.accessioned2023-09-26T21:14:09Z
dc.date.available2023-09-26T21:14:09Z
dc.identifierSPANGENBERG, Lucia et al. Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. PLoS ONE, v. 8, n. 10, p. 1-13, 2013.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16017
dc.identifier10.1371/journal.pone.0075578
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871268
dc.descriptionMinistério da Saúde and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico-CNPq, FIOCRUZ, Pasteur Research Program and Fundação Araucaria.
dc.descriptionPost-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post-transcriptional regulation mechanisms, such as alternative polyadenylation. This would involve changes in protein binding, transcript usage, miRNAs and other non-coding RNAs. In the present work we analyzed the distribution of alternative transcripts during adipogenic differentiation and the potential role of miRNAs in post-transcriptional regulation. Our in silico analysis suggests a modest, consistent, bias in 3′UTR lengths during differentiation enabling a fine-tuned transcript regulation via small non-coding RNAs. Including these effects in the analyses partially accounts for the observed discrepancies in relative abundance of protein and mRNA.
dc.formatapplication/pdf
dc.languageeng
dc.publisherIratxe Puebla
dc.rightsopen access
dc.subjectAlternative Polyadenylation
dc.subjectAdipogenic Differentiation
dc.subjectMesenchymal stem cells
dc.subjectPoliadenilação
dc.subjectDiferenciação Celular
dc.subjectCélulas Mesenquimais Estromais
dc.titleRole of alternative polyadenylation during adipogenic differentiation: an in silico approach
dc.typeArticle


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