Immune outcomes of Zika virus infection in nonhuman primates

dc.creatorSchouest, Blake
dc.creatorFahlberg, Marissa
dc.creatorScheef, Elizabeth A.
dc.creatorWard, Matthew J.
dc.creatorHeadrick, Kyra
dc.creatorSzeltner, Dawn M.
dc.creatorBlair, Robert V.
dc.creatorGilbert, Margaret H.
dc.creatorDoyle‑Meyers, Lara A.
dc.creatorDanner, Victoria W.
dc.creatorBonaldo, Myrna C.
dc.creatorWesson, Dawn M.
dc.creatorPanganiban, Antonito T.
dc.creatorManess, Nicholas J.
dc.date2021-06-17T15:06:42Z
dc.date2021-06-17T15:06:42Z
dc.date2020
dc.date.accessioned2023-09-26T21:12:34Z
dc.date.available2023-09-26T21:12:34Z
dc.identifierSCHOUEST, Blake et al. Immune outcomes of Zika virus infection in nonhuman primates. Scientific Reports, v. 10, 13069, p. 1-12, 2020.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/47748
dc.identifier10.1038/s41598-020-69978-w
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870861
dc.descriptionAlthough the Zika virus (ZIKV) epidemic is subsiding, immune responses that are important for controlling acute infection have not been defnitively characterized. Nonhuman primate (NHP) models were rapidly developed to understand the disease and to test vaccines, and these models have since provided an understanding of the immune responses that correlate with protection during natural infection and vaccination. Here, we infected a small group of male rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques with a minimally passaged Brazilian ZIKV isolate and used multicolor fow cytometry and transcriptional profling to describe early immune patterns following infection. We found evidence of strong innate antiviral responses together with induction of neutralizing antibodies and T cell responses. We also assessed the relative importance of CD8 T cells in controlling infection by carrying out CD8 T cell depletion in an additional two animals of each species. CD8 depletion appeared to dysregulate early antiviral responses and possibly increase viral persistence, but the absence of CD8 T cells ultimately did not impair control of the virus. Together, these data describe immunological trends in two NHP species during acute ZIKV infection, providing an account of early responses that may be important in controlling infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Research
dc.rightsopen access
dc.subjectVírus da Zika
dc.subjectResultados imunes
dc.subjectInfecção
dc.subjectPrimatas não humanos
dc.subjectZika virus
dc.subjectInfection
dc.subjectNonhuman primates
dc.subjectImmune outcomes
dc.titleImmune outcomes of Zika virus infection in nonhuman primates
dc.typeArticle


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