Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C

dc.creatorLima, Raul Emídio de
dc.creatorMartins, Cyntia Maria Holanda
dc.creatorCarmo, Rodrigo Feliciano do
dc.creatorAroucha, Dayse Celia Barbosa Lins
dc.creatorPereira, Leila Maria Moreira Beltrão
dc.creatorVasconcelos, Luydson Richardson Silva
dc.creatorMoura, Patrícia
dc.date2019-04-22T16:10:16Z
dc.date2019-04-22T16:10:16Z
dc.date2018
dc.date.accessioned2023-09-26T21:11:34Z
dc.date.available2023-09-26T21:11:34Z
dc.identifierLIMA, Raul Emídio de et al. Two Sides of a Coin: GG Genotype of C7 Provides Protection against Fibrosis Severity While Showing a Higher Risk for Hepatocellular Carcinoma in Patients with Hepatitis C. Human Immunology, v. 79, n. 9, p. 702-707, Sept. 2018.
dc.identifier1879-1166
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32668
dc.identifier10.1016/j.humimm.2018.06.009
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870612
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior ( CAPES ), Fundação de Amparo à Pesquisa do Estado de Pernambuco ( FACEPE ; outorga: APQ-1554-4.01 / 15 ) e Conselho Nacional de Desenvolvimento Científico e Tecnológico ( CNPq ; outorga: 409681 / 2016- 4 )
dc.descriptionThe complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination. Patients were classified by their METAVIR score as F1 (n = 100), F2 (n = 83), F3 (n = 101) or F4 (n = 66); 106 patients were diagnosed with HCC. Patients carrying the G/G genotype of C7 had a lower chance of developing severe fibrosis in the recessive model (p = 0.042; OR: 0.65 95% CI 0.41-1.02). However, the G/G genotype frequency was higher in patients with HCC (P = 0.01; OR: 2.07 95% CI 1.20-3.53) and in those with larger tumors (p = 0.04). The G/G C7 genotype seems to be a protective factor against advanced fibrosis; however, it was associated with a higher risk of HCC and the occurrence of larger hepatic nodules, suggesting the involvement of C7 in the physiopathogenesis of HCC and fibrosis in patients with hepatitis C virus (HCV).
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectPolymorphism
dc.subjectComplement system
dc.subjectC7
dc.subjectHCV
dc.subjectAdulto
dc.subjectEnvelhecido
dc.subjectAlelos
dc.subjectCarcinoma Hepatocelular / genética
dc.subjectComplemento C7 / genética
dc.subjectComplexo de ataque à membrana do complemento / metabolismo
dc.subjectFêmea
dc.subjectFibrose
dc.subjectPredisposição Genética para Doença
dc.subjectGenótipo
dc.subjectHepacivirus / fisiologia
dc.subjectHepatite C, Crônica / genética
dc.subjectHumanos
dc.subjectFígado / patologia
dc.subjectFígado / fisiologia
dc.subjectNeoplasias Hepáticas / genética
dc.subjectMasculino
dc.subjectMeia idade
dc.subjectPolimorfismo de Nucleotídeo Único
dc.titleTwo sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C
dc.typeArticle


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