Stem cell ribonomics: RNA-binding proteins and gene networks in Stem cell differentiation

dc.creatorShigunov, Patrícia
dc.creatorDallagiovanna, Bruno
dc.date2017-08-18T13:29:54Z
dc.date2017-08-18T13:29:54Z
dc.date2015
dc.date.accessioned2023-09-26T21:11:28Z
dc.date.available2023-09-26T21:11:28Z
dc.identifierSHIGUNOV P.; DALLAGIOVANNA B. Stem cell ribonomics: RNA-binding proteins and gene networks in Stem cell differentiation. Frontiers in Molecular Biosciences, v. 2, n. 74, p. 1-7, 2015.
dc.identifier2296-889X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20676
dc.identifier10.3389/fmolb.2015.00074
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870581
dc.descriptionStem cells are undifferentiated cells with the ability to self-renew and the potential to differentiate into all body cell types. Stem cells follow a developmental genetic program and are able to respond to alterations in the environment through various signaling pathways. The mechanisms that control these processes involve the activation of transcription followed by a series of post-transcriptional events. These post-transcriptional steps are mediated by the interaction of RNA-binding proteins (RBPs) with defined subpopulations of RNAs creating a regulatory gene network. Characterizing these RNA-protein networks is essential to understanding the regulatory mechanisms underlying the control of stem cell fate. Ribonomics is the combination of classical biochemical purification protocols with the high-through put identification of transcripts applied to the functional characterization of RNA-protein complexes. Here, we describe the different approaches that can be used in a ribonomic approach and how they have contributed to understanding the function of several RBPs with central roles in stem cell biology.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectDiferenciação Celular
dc.subjectRibonomics
dc.subjectRNA-Binding Proteins
dc.subjectStem Cells
dc.subjectGene Regulatory Networks
dc.subjectCell Differentiation
dc.subjectProteínas de Unión al ARN
dc.subjectCélulas Madre
dc.subjectRedes Reguladoras de Genes
dc.subjectDiferenciación Celular
dc.subjectProteínas de Ligação a RNA
dc.subjectCélulas-Tronco
dc.subjectRedes Reguladoras de Genes
dc.titleStem cell ribonomics: RNA-binding proteins and gene networks in Stem cell differentiation
dc.typeArticle


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