Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys

dc.creatorCarvalho, Leonardo J, de Moura
dc.creatorAlves, Francisco Acácio
dc.creatorOliveira, Salma Gomes de
dc.creatorValle, Rodrigo del Rio do
dc.creatorFernandes, Andréa A. Morais
dc.creatorMuniz, José A. Pereira Carneiro
dc.creatorDaniel-Ribeiro, Claudio T.
dc.date2020-11-14T14:45:00Z
dc.date2020-11-14T14:45:00Z
dc.date2003
dc.date.accessioned2023-09-26T21:09:27Z
dc.date.available2023-09-26T21:09:27Z
dc.identifierCARVALHO, Leonardo J. de Moura et al. Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 5, p. 679-686, July 2003.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44411
dc.identifier10.1590/S0074-02762003000500016
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8870056
dc.descriptionSevere anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectMalária
dc.subjectPlasmodium falciparum
dc.subjectAotus infulatus
dc.subjectModelo primata
dc.subjectMalaria
dc.subjectPlasmodium falciparum
dc.subjectAotus infulatus
dc.subjectPrimate model
dc.titleSevere anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys
dc.typeArticle


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