Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

dc.creatorBoni, Raquel B. de
dc.creatorZheng, Lu
dc.creatorRosenkranz, Susan L.
dc.creatorSun, Xin
dc.creatorLavenberg, Jeffrey
dc.creatorCardoso, Sandra W.
dc.creatorGrinsztejn, Beatriz
dc.creatorLa Rosa, Alberto
dc.creatorPierre, Samuel
dc.creatorSevere, Patrice
dc.creatorCohn, Susan E.
dc.creatorCollier, Ann C.
dc.creatorGross, Robert
dc.date2018-10-03T16:18:53Z
dc.date2018-10-03T16:18:53Z
dc.date2016
dc.date.accessioned2023-09-26T21:08:48Z
dc.date.available2023-09-26T21:08:48Z
dc.identifierBONI, Raquel B. de et al. Binge Drinking Is Associated with Differences in Weekday and Weekend Adherence in HIV-Infected Individuals. Drug and alcohol dependence, v. 159, p. 174-180, 2016.
dc.identifier0376-8716
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29289
dc.identifier10.1016/j.drugalcdep.2015.12.013
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869882
dc.descriptionBackground—Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: 1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and 2) whether binge drinking was associated with this difference. Methods—Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results—Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1–4 respectively, all p<0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions—Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectAlcohol
dc.subjectBinge drinking
dc.subjectHIV/AIDS
dc.subjectAdherence
dc.subjectMicroelectronic monitors
dc.subjectLow and middle income countries
dc.titleBinge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals
dc.typeArticle


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